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抗人CD83抗体，克隆HB15e

抗人、恒河猴、食蟹猴CD83的小鼠单克隆IgG1抗体
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产品号 #60107_C

抗人、恒河猴、食蟹猴CD83的小鼠单克隆IgG1抗体

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总览
实验数据
产品说明书及文档
应用领域
相关材料与文献
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总览

HB15e抗体可特异性识别CD83。CD83是一种分子量约为45 kDa的I型跨膜糖蛋白，属于Siglec蛋白家族，含有胞外V型免疫球蛋白样结构域和C端胞质尾。CD83的一种可溶性形式也已被确定。CD83主要表达于循环和组织树突状细胞，包括Langerhan细胞和交错网状细胞。它在活化淋巴细胞中表达较弱，也可能表达于中性粒细胞、单核细胞和巨噬细胞中。除了树突状细胞外，CD83的表达通常是短暂的，并且与HLA II类抗原的上调相关。它的功能虽然不明确，但对免疫系统的发育和维持至关重要，有证据表明它可能参与细胞粘附和信号传导、抗原递呈以及淋巴细胞活化。CD83的可溶性形式似乎具有免疫抑制作用。研究发现，HB15e抗体结合的CD83表位与抗体1E11的表位重叠。

亚型
一抗
 
靶抗原
CD83
 
别名
B细胞活化蛋白，BL11，HB15
 
活性物种
Baboon，Chimpanzee，Cynomolgus，人，Macaque，Rhesus
 
偶联
Alexa Fluor 488，APC，Biotin 或 生物素，FITC，PE，未偶联的
 
宿主物种
小鼠
 
细胞类型
树突状细胞（DCs）
 
种属
人，非人灵长类
 
应用
流式细胞术，免疫印迹，免疫组化
 
研究领域
免疫
 
克隆
HB15e
 
基因编号
9308
 
同种型
IgG1，kappa
 

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Data Figures

Data for Unconjugated

Figure 1. Data for Unconjugated

Flow cytometry analysis of dendritic cells derived from human peripheral blood mononuclear cells (PBMCs). Cells were processed with the EasySep™ Human CD14 Positive Selection Kit (Catalog #18058) and labeled with Anti-Human CD83 Antibody, Clone HB15e, followed by a rat anti-mouse IgG1 antibody, PE (filled histogram), or a mouse IgG1, kappa isotype control antibody followed by a rat anti-mouse IgG1 antibody, PE (solid line histogram).

Data for Alexa Fluor® 488-Conjugated

Figure 2. Data for Alexa Fluor® 488-Conjugated

Flow cytometry analysis of dendritic cells derived from human peripheral blood mononuclear cells (PBMCs). Cells were processed with the EasySep™ Human CD14 Positive Selection Kit (Catalog #18058) and labeled with Anti-Human CD83 Antibody, Clone HB15e, Alexa Fluor® 488 (filled histogram) or a mouse IgG1, kappa isotype control antibody, Alexa Fluor® 488 (solid line histogram).

Data for APC-Conjugated

Figure 3. Data for APC-Conjugated

Flow cytometry analysis of dendritic cells derived from human peripheral blood mononuclear cells (PBMCs). Cells were processed with the EasySep™ Human CD14 Positive Selection Kit (Catalog #18058) and labeled with Anti-Human CD83 Antibody, Clone HB15e, APC (filled histogram) or a mouse IgG1, kappa isotype control antibody, APC (solid line histogram).

Data for Biotin-Conjugated

Figure 4. Data for Biotin-Conjugated

Flow cytometry analysis of dendritic cells derived from human peripheral blood mononuclear cells (PBMCs). Cells were processed with the EasySep™ Human CD14 Positive Selection Kit (Catalog #18058) and labeled with Anti-Human CD83 Antibody, Clone HB15e, Biotin followed by streptavidin (SAV) APC (filled histogram), or a biotinylated mouse IgG1, kappa isotype control antibody followed by SAV APC (solid line histogram).

Data for FITC-Conjugated

Figure 5. Data for FITC-Conjugated

Flow cytometry analysis of dendritic cells derived from human peripheral blood mononuclear cells (PBMCs). Cells were processed with the EasySep™ Human CD14 Positive Selection Kit (Catalog #18058) and labeled with Anti-Human CD83 Antibody, Clone HB15e, FITC (filled histogram) or a mouse IgG1, kappa isotype control antibody, FITC (solid line histogram).

Data for PE-Conjugated

Figure 6. Data for PE-Conjugated

Flow cytometry analysis of dendritic cells derived from human peripheral blood mononuclear cells (PBMCs). Cells were processed with the EasySep™ Human CD14 Positive Selection Kit (Catalog #18058) and labeled with Anti-Human CD83 Antibody, Clone HB15e, PE (filled histogram) or a mouse IgG1, kappa isotype control antibody, PE (solid line histogram).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD83 Antibody, Clone HB15e, APC
Catalog #
60107AZ, 60107AZ.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD83 Antibody, Clone HB15e, FITC
Catalog #
60107FI.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD83 Antibody, Clone HB15e, PE
Catalog #
60107PE, 60107PE.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD83 Antibody, Clone HB15e, APC
Catalog #
60107AZ, 60107AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD83 Antibody, Clone HB15e, FITC
Catalog #
60107FI.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD83 Antibody, Clone HB15e, PE
Catalog #
60107PE, 60107PE.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (2)

Reliable Antibodies for Your Research
Brochure
Reliable Antibodies for Your Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

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更多信息
Species Human, Non-Human Primate
Clone HB15e
Gene Id 9308
Alternative Names B-cell activation protein, BL11, HB15
Isotype IgG1, kappa
Legal Statement: Alexa Fluor is a registered trademark of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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