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抗人CD43 抗体，克隆CD43-10G7

小鼠单克隆IgG1抗体，抗人CD43
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产品号 #60085_C

小鼠单克隆IgG1抗体，抗人CD43

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总览
实验数据
产品说明书及文档
应用领域
相关材料与文献
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总览

CD43-10G7抗体识别人CD43，CD43是一种表达在大多数人造血细胞表面的I型跨膜唾液糖蛋白，包括胸腺细胞、外周T细胞、NK细胞、单核细胞、粒细胞、一些B细胞（骨髓中活化的B细胞和早期B细胞亚群）、浆细胞和造血祖细胞。在血小板上的表达水平较低。根据细胞类型的不同，CD43在~95 - 135 kDa范围内表现出不同的糖型（glycoforms）。它结合CD54和CD169 （Siglec1）等配体，在细胞粘附和活化、细胞凋亡和肿瘤进展中发挥调节作用，是组织内区分正常与肿瘤T细胞和B细胞的标志物。据报道，CD43- 10G7抗体与中性粒细胞上的CD43结合可诱导同型细胞粘附。

亚型
一抗
 
靶抗原
CD43
 
别名
白细胞唾液酸糖蛋白，白细胞唾液酸素蛋白，Ly-48，唾液蛋白，W3/13
 
活性物种
人
 
偶联
APC，PE，未偶联的
 
宿主物种
小鼠
 
细胞类型
B 细胞
 
种属
人
 
应用
流式细胞术，功能学筛选，免疫沉淀
 
研究领域
免疫
 
克隆
CD43-10G7
 
基因编号
6693
 
同种型
IgG1，kappa
 

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Data Figures

Data for APC-Conjugated

Figure 1. Data for APC-Conjugated

(A) Flow cytometry analysis of human buffy coat nucleated cells labeled with Anti-Human CD43 Antibody, Clone CD43-10G7, APC and Anti-Human CD45 Antibody, Clone HI30, PE (Catalog #60018PE).
(B) Flow cytometry analysis of human buffy coat nucleated cells processed with the EasySep™ HLA Whole Blood B Cell Positive Selection Kit and labeled with Anti-Human CD43 Antibody, Clone CD43-10G7, APC and Anti-Human CD45 Antibody, Clone HI30, PE. Note: CD43 is not expressed on resting B cells.
(C) Flow cytometry analysis of human buffy coat nucleated cells labeled with a mouse IgG1, kappa APC isotype control antibody and Anti-Human CD45 Antibody, Clone HI30, PE.

Data for PE-Conjugated

Figure 2. Data for PE-Conjugated

(A) Flow cytometry analysis of human buffy coat nucleated cells labeled with Anti-Human CD43 Antibody, Clone CD43-10G7, PE and Anti-Human CD45 Antibody, Clone HI30, APC (Catalog #60018AZ).
(B) Flow cytometry analysis of human buffy coat nucleated cells processed with the EasySep™ HLA Whole Blood B Cell Positive Selection Kit and labeled with Anti-Human CD43 Antibody, Clone CD43-10G7, PE and Anti-Human CD45 Antibody, Clone HI30, APC. Note: CD43 is not expressed on resting B cells.
(C) Flow cytometry analysis of human buffy coat nucleated cells labeled with a mouse IgG1, kappa PE isotype control antibody and Anti-Human CD45 Antibody, Clone HI30, APC.

Data for Unconjugated

Figure 3. Data for Unconjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD43 Antibody, Clone CD43-10G7, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI) (filled histogram), or a mouse IgG1, kappa isotype control antibody, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (solid line histogram).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD43 Antibody, Clone CD43-10G7, PE
Catalog #
60085PE, 60085PE.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD43 Antibody, Clone CD43-10G7, APC
Catalog #
60085AZ, 60085AZ.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD43 Antibody, Clone CD43-10G7
Catalog #
60085
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD43 Antibody, Clone CD43-10G7, PE
Catalog #
60085PE, 60085PE.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD43 Antibody, Clone CD43-10G7, APC
Catalog #
60085AZ, 60085AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD43 Antibody, Clone CD43-10G7
Catalog #
60085
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Reliable Antibodies for Your Research
Brochure
Reliable Antibodies for Your Research
Tools for Your Immunology Research
Brochure
Tools for Your Immunology Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

更多信息

更多信息
Species Human
Clone CD43-10G7
Gene Id 6693
Alternative Names Leukocyte sialoglycoprotein, Leukosialin, Ly-48, Sialophorin, W3/13
Isotype IgG1, kappa
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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