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抗人CD36抗体，克隆FA6-152

小鼠单克隆IgG1抗体，抗人、大鼠CD36
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产品号 #（选择产品）

产品号 #60084_C

小鼠单克隆IgG1抗体，抗人、大鼠CD36

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总览
实验数据
产品说明书及文档
应用领域
相关材料与文献
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总览

FA6-152抗体识别CD36，CD36是一种~88 kDa的跨膜糖蛋白，在多种类型的细胞（包括血小板、单核细胞、巨噬细胞、红细胞前体、内皮细胞和上皮细胞以及某些巨噬细胞来源的树突状细胞）表面起着清道夫受体、细胞粘附分子和信号转导的作用。该蛋白的拓扑结构被认为包括一个大的细胞外环，其N和C端都穿过细胞膜。CD36结合血小板反应蛋白、胶原蛋白、脂蛋白、长链脂肪酸等多种配体，在凋亡细胞的吞噬清除、抑制血管生成、葡萄糖和脂肪酸代谢、炎症、疟疾发病等方面具有明显作用。据报道，FA6-152抗体与CD36结合可阻断其与血小板反应蛋白、胶原蛋白、凋亡细胞和修饰的LDL的相互作用，并诱导胎儿红细胞凝集，但不诱导成人红细胞凝集。据报道，FA6-152的表位位于CD36的免疫优势结构域内，该结构域由氨基酸155 - 183组成。

亚型
一抗
 
靶抗原
CD36
 
别名
GP88，GPIIIb，GPIV，FAT，血小板糖蛋白4，血小板糖蛋白IIIb，血小板糖蛋白IV，SCARB3，血栓调节蛋白受体
 
活性物种
人，大鼠
 
偶联
FITC，未偶联的
 
宿主物种
小鼠
 
细胞类型
单核细胞，其它细胞系
 
种属
人，大鼠
 
应用
细胞分选，流式细胞术，功能学筛选，免疫细胞化学，免疫荧光，免疫组化，免疫沉淀，中和及阻断，Western印迹
 
研究领域
免疫
 
克隆
FA6-152
 
基因编号
948
 
同种型
IgG1，kappa
 

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Data Figures

Data for Unconjugated

Figure 1. Data for Unconjugated

(A) Flow cytometry analysis of human erythroleukemia (HEL) cells labeled with Anti-Human CD36 Antibody, Clone FA6-152, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI) (filled histogram), or a mouse IgG1, kappa isotype control antibody, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (solid line histogram). (B) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD36 Antibody, Clone FA6-152, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (filled histogram), or a mouse IgG1, kappa isotype control antibody, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (solid line histogram).

Data for FITC-Conjugated

Figure 2. Data for FITC-Conjugated

(A) Flow cytometry analysis of human erythroleukemia (HEL) cells labeled with Anti-Human CD36 Antibody, Clone FA6-152, FITC (filled histogram) or a mouse IgG1, kappa FITC isotype control antibody (solid line histogram). (B) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD36 Antibody, Clone FA6-152, FITC (filled histogram) or a mouse IgG1, kappa FITC isotype control antibody (solid line histogram). (C) Flow cytometry analysis of human PBMCs processed with the EasySep™ Human CD14 Positive Selection Kit and labeled with Anti-Human CD36 Antibody, Clone FA6-152, FITC. Histograms show labeling of PBMCs (Start) and isolated cells (Isolated). Labeling of start cells with a mouse IgG1, kappa FITC isotype control antibody is shown (solid line histogram).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD36 Antibody, Clone FA6-152
Catalog #
60084
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD36 Antibody, Clone FA6-152, FITC
Catalog #
100-1577
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD36 Antibody, Clone FA6-152
Catalog #
60084
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD36 Antibody, Clone FA6-152, FITC
Catalog #
100-1577
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Reliable Antibodies for Your Research
Brochure
Reliable Antibodies for Your Research
Tools for Your Immunology Research
Brochure
Tools for Your Immunology Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

更多信息

更多信息
Species Human, Rat
Clone FA6-152
Gene Id 948
Alternative Names GP88, GPIIIb, GPIV, FAT, platelet glycoprotein 4, platelet glycoprotein IIIb, platelet glycoprotein IV, SCARB3, thrombospondin receptor
Isotype IgG1, kappa
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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