产品号 #60127_C
Mouse monoclonal antibody against human, chimpanzee CD3
概述
This monoclonal antibody reacts with the ~20 kDa cluster of differentiation 3 epsilon (CD3ε) subunit of human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ~95% of mature T cells and natural killer T cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. The CD3 complex consists of subunits γ, δ, ε, η, and ζ and binds noncovalently with the TCR. It is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating expression of the TCR on cell surfaces. Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related to type 1 transmembrane proteins and members of the immunoglobulin superfamily. Mutations in the CD3 subunits have been associated with various immunodeficiency disorders including severe combined immunodeficiency (SCID).
Subtype
Primary Antibodies
Target Antigen
CD3
Reactive Species
Chimpanzee, Human
Conjugation
APC, FITC, PE, PerCP
Host Species
Mouse
Cell Type
T Cells
Species
Human, Non-Human Primate
Application
Cell Isolation, Flow Cytometry
Area of Interest
Immunology
Clone
SK7
Gene ID
916
Data Figures
Figure 1. Data for FITC Conjugated
Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD3 Antibody, Clone SK7, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI; solid line histogram).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Human CD3 Antibody, Clone SK7, APC Catalog #
100-1591 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human CD3 Antibody, Clone SK7, FITC Catalog #
60127FI, 60127FI.1 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human CD3 Antibody, Clone SK7, PE Catalog #
100-1592 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human CD3 Antibody, Clone SK7, PerCP Catalog #
100-1590 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD3 Antibody, Clone SK7, APC Catalog #
100-1591 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD3 Antibody, Clone SK7, FITC Catalog #
60127FI, 60127FI.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD3 Antibody, Clone SK7, PE Catalog #
100-1592 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD3 Antibody, Clone SK7, PerCP Catalog #
100-1590 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Dendritic Cell Research
Workflow Stages for HLA Analysis
Resources and Publications
Educational Materials (3)
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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