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Annexin V

一种检测凋亡细胞的细胞蛋白
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产品号 #100-0328_C

一种检测凋亡细胞的细胞蛋白

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总览
实验数据
产品说明书及文档
应用领域
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总览

Annexin V属于胞内膜联蛋白家族，以钙依赖的方式与膜磷脂结合。这种染料对存在于质膜内小叶中的磷脂酰丝氨酸（PS）有很高的亲和力。在早期细胞凋亡过程中，PS从胞膜的内叶向外叶易位，暴露于胞外环境中。Annexin V是早期细胞凋亡的特征性标志物，可检测PS向胞外环境的易位。Annexin V与7-AAD（产品号 #75001）或碘化丙啶（PI，产品号 #75002）等活性染料一起使用。由于PS易位的过程发生在细胞膜完整性丧失之前，当细胞经历凋亡并走向坏死时，细胞膜受损，导致活性染料进入细胞。因此，发生早期凋亡的细胞Annexin V染色阳性，活性染料染色阴性，而细胞凋亡性死亡或坏死的特征是Annexin V和活性染料染色双阳性。

偶联
APC，FITC，PE
 
应用
流式细胞术
 
研究领域
免疫
 

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Data Figures

Figure showing flow cytometry analysis of C57BL/6 mouse thymocytes incubated at 37°C with 1 µM dexamethasone overnight. Cells were harvested and labeled with APC Annexin V and 7-AAD.

Figure 1. Data for Annexin V, APC

Flow cytometry analysis of C57BL/6 mouse thymocytes incubated at 37°C with 1 µM dexamethasone overnight. Cells were harvested and labeled with APC-conjugated Annexin V and 7-AAD (Catalog #75001).

Figure showing flow cytometry analysis of Con-A stimulated (3 days) C57BL/6 mouse splenocytes labeled with Anti-Mouse CD152 (CTLA-4) Antibody, Clone UC10-4F10-11, PE or an Armenian hamster IgG, PE isotype control antibody.

Figure 2. Data for Annexin V, FITC

Figure showing flow cytometry analysis of C57BL/6 mouse thymocytes incubated at 37°C with 1 µM dexamethasone overnight. Cells were harvested and labeled with FITC Annexin V and 7-AAD.

Figure showing flow cytometry analysis of Con A-stimulated (3 days) C57BL/6 mouse splenocytes labeled with Anti-Mouse CD152 (CTLA-4) Antibody, Clone UC10-4F10-11, followed by a goat anti-Armenian hamster IgG antibody, FITC or an Armenian hamster IgG isotype control antibody, followed by a goat anti-Armenian hamster IgG, FITC.

Figure 3. Data for Annexin V, PE

Figure showing flow cytometry analysis of C57BL/6 mouse thymocytes incubated at 37°C with 1 µM dexamethasone overnight. Cells were harvested and labeled with PE Annexin V and 7-AAD.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Annexin V, APC
Catalog #
100-0328, 100-0329
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Annexin V, FITC
Catalog #
100-0333, 100-0332
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Annexin V, PE
Catalog #
100-0330, 100-0331
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Annexin V, APC
Catalog #
100-0328, 100-0329
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Annexin V, FITC
Catalog #
100-0333, 100-0332
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Annexin V, PE
Catalog #
100-0330, 100-0331
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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