产品号 #72022_C
Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7
概述
A 83-01 is a potent inhibitor of activin receptor-like kinase (ALK) including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with IC₅₀ = 12, 45, and 7.5 nM, respectively (Tojo et al.).
MAINTENANCE AND SELF-RENEWAL
· Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.).
REPROGRAMMING
· In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.).
DIFFERENTIATION
· Inhibits mesoderm and endoderm specification (Zhang et al.).
· Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.).
Cell Type
Pluripotent Stem Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Differentiation, Maintenance, Reprogramming
Area of Interest
Stem Cell Biology
CAS Number
909910-43-6
Chemical Formula
<div>
C<font face="Cambria Math">₂₅</font>H<font face="Cambria Math">₁₉</font>N<font face="Cambria Math">₅</font>S
Purity
≥ 95%
Pathway
Activin/Nodal/TGFβ
Target
ALK5
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
A 83-01 Catalog #
100-1041, 72024, 72022, 100-0245 Lot #
Lot# 1000028286 or higher for 72022 | Lot# 1000028287 or higher for 72024 | Lot# 1000027271 or higher for 100-0245 | Lot# 1000103072 or higher for 100-1041 Language
English Document Type
Safety Data Sheet Product Name
A 83-01 Catalog #
72024, 72022, 100-0245 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Human Pluripotent Stem Cell Research
Workflow Stages for hPSC-Derived Neural Cell Research
Workflow Stages for hPSC-Derived Mesoderm Cell Research
Workflow Stages for Mouse Pluripotent Stem Cell Research
Resources and Publications
Educational Materials (6)
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