产品号 #72742_C
Antibiotic; Used in Tet-inducible gene expression systems
概述
Doxycycline is a tetracycline-like antibiotic (Hicks et al.; Nau et al.; Solís García del Pozo & Solera; Steinhardt et al.). In genetic engineering, doxycycline is used as the regulator for inducible gene expression systems, whereby expression depends on either the presence (Tet-On) or absence (Tet-Off ) of doxycycline. Also, doxycycline inhibits certain matrix metalloproteinases (MMP), such as MMP-8 (Ki = 36 µM; Griffin et al.; Smith et al.). It only poorly inhibits MMP-1 and MMP-13 (Ki > 100 µM; Smith et al.). This product is supplied as the hyclate salt of the molecule.
CELL LINE DEVELOPMENT
· Used as the regulator for inducible gene expression in lentiviral infection and transgenic mouse models using the Tet-On or Tet-Off systems (Brambrink et al.; Carey et al.; Haenebalcke et al.; Hanna et al.; Hockemeyer et al.; Maherali et al.; Markoulaki et al.; Stadtfeld et al. 2008, 2010; Wernig et al.).
Alternative Names
WC 2031
Cell Type
CHO Cells, Pluripotent Stem Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Antibiotic
Area of Interest
Cell Line Development
CAS Number
24390-14-5
Chemical Formula
2[C₂₂H₂₄N₂O₈] · 2HCl · H₂O · C₂H₆O
Molecular Weight
1025.9 g/mol
Purity
≥ 98%
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Doxycycline (Hyclate) Catalog #
72742, 100-1047 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Doxycycline (Hyclate) Catalog #
72742 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Doxycycline (Hyclate) Catalog #
100-1047 Lot #
All Language
English Request Pricing
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE. Safety Statement: CA WARNING: This product can expose you to Doxycycline hyclate (internal use) which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov
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