Anti-SHIP Antibody, Polyclonal

Rabbit polyclonal antibody against mouse SHIP

产品号 #60141_C

Rabbit polyclonal antibody against mouse SHIP

概述

The SH2-containing inositol phosphatase (SHIP, also called SHIP1) is a 145 kDa hematopoietic-restricted protein that becomes tyrosine-phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse full-length SHIP protein, 145 kDa, as well as the C-terminal truncated 135, 125, and 110 kDa forms.

Subtype
Primary Antibodies
 
Target Antigen
SHIP
 
Alternative Names
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; p150Ship; SHIP1; SHIP-1; s-SHIP; SIP-145
 
Reactive Species
Human, Mouse
 
Conjugation
Unconjugated
 
Host Species
Rabbit
 
Cell Type
Granulocytes and Subsets, Lymphocytes, Myeloid Cells
 
Species
Human, Mouse
 
Application
Immunoblotting, Immunoprecipitation
 
Area of Interest
Immunology
 
Clone
Not applicable
 
Gene ID
16331
 
Isotype
Not applicable
 

Data Figures

Western blot analysis of mouse bone marrow derived mast cells (BMMCs) from normal (+/+) and SHIP knockout (-/-) mice with Anti-SHIP Antibody, Polyclonal (1:4000 dilution). SHIP has a predicted molecular mass of 145 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
60141
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
60141
Lot #
All
Language
English

Resources and Publications

Educational Materials (2)

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