产品号 #60160_C
Hamster (Armenian) monoclonal IgG1 antibody against human, mouse, rat CD27
概述
The LG.3A10 antibody reacts with CD27, a 45 - 55 kDa member of the tumor necrosis factor receptor superfamily. CD27 is found on peripheral T cells, memory B cells, and NK cells and in mice has been found on most thymocytes, except CD46-CD8- precursors. CD27 and its ligand CD70 are involved in multiple aspects of T cell biology, including the costimulation and expansion of CD4+ and CD8+ T cells and differentiation to memory CD8+ T cells. CD27 interacts with TRAF family members, resulting in enhanced cellular proliferation and the induction of anti-apoptotic proteins. Additionally, CD27 plays important roles in T cell – B cell interactions and the maturation of effector T cells. The expansion of activated B cells and their differentiation to plasma cells is also reported to be enhanced by CD27.
Subtype
Primary Antibodies
Target Antigen
CD27
Alternative Names
LPFS2, S152, T14, TNFRSF7, Tp55
Reactive Species
Human, Mouse, Rat
Conjugation
PE, Unconjugated
Host Species
Hamster
Cell Type
B Cells, NK Cells, Other, T Cells
Application
Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation
Area of Interest
Immunology, Infectious Diseases
Clone
LG.3A10
Gene ID
21940/939/500318
Isotype
IgG1, kappa
Data Figures
Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD27 Antibody, Clone LG.3A10, followed by a goat anti-hamster (Armenian) IgG antibody, Alexa Fluor® 488 (filled histogram), or an Armenian hamster IgG isotype control antibody, followed by a goat anti-hamster (Armenian) IgG antibody, Alexa Fluor® 488 (solid line histogram).
Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD27 Antibody, Clone LG.3A10, PE (filled histogram) or an Armenian hamster IgG isotype control antibody, PE (solid line histogram).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Mouse CD27 Antibody, Clone LG.3A10, PE Catalog #
60160PE.1 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD27 Antibody, Clone LG.3A10 Catalog #
60160 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD27 Antibody, Clone LG.3A10, PE Catalog #
60160PE.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD27 Antibody, Clone LG.3A10 Catalog #
60160 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for B Cell Research
Workflow Stages for Natural Killer Cell Research
Resources and Publications
Educational Materials (2)
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