产品号 #100-1461_C
Mouse monoclonal IgG1 antibody against human TNF-alpha
概述
This mouse monoclonal antibody (clone MT15B15) reacts with human tumor necrosis factor alpha (TNF-α). TNF-α is a pro-inflammatory cytokine primarily produced by macrophages and T cells in response to infection and inflammation. Initially generated as a ~26 kDa transmembrane precursor, TNF-α is then processed by metalloproteinases into a ~17 kDa soluble product. Both forms of TNF-α are active in trimeric form and exert their effects via binding to either TNFR1, present on the surface of nearly all human cell types, or TNFR2, which is localized to immune and endothelial cells. First described as having tumor-necrotic action, TNF-α signaling results in an inflammatory response that includes vasodilation and edema formation, adhesion of leukocytes to the epithelium, and blood coagulation. TNF-α also plays a key role in defense against bacterial, viral, and parasitic infections.
Target Antigen
TNF-alpha
Alternative Names
Cachectin, DIF, DIF-alpha, differentiation inducing factor, TNF, TNF-α, TNF-a, TNFa, TNFA, TNFSF2, TNLG1F, tumor necrosis factor, tumor necrosis factor-α
Reactive Species
Human
Conjugation
Biotin, PF488P, PF647P
Host Species
Mouse
Cell Type
Macrophages, T Cells
Species
Human
Application
Flow Cytometry
Area of Interest
Immunology
Clone
MT15B15
Gene ID
7124
Isotype
IgG1
Data Figures
Figure 1. Data for Anti-Human TNF-alpha Antibody, Clone MT15B15, PF647P
(A) Flow cytometry analysis of unstimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human TNF-alpha Antibody, Clone MT15B15, PF647P and anti-human CD8a antibody, clone RPA-T8, PE (Catalog #60022PE). (B) Flow cytometry analysis of PMA/ionomycin-stimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human TNF-alpha Antibody, Clone MT15B15, PF647P and anti-human CD8a antibody, clone RPA-T8, PE (Catalog #60022PE).
Figure 2. Data for Anti-Human TNF-alpha Antibody, Clone MT15B15, PF488P
(A) Flow cytometry analysis of unstimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human TNF-alpha Antibody, Clone MT15B15, PF488P and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1). (B) Flow cytometry analysis of PMA/ionomycin-stimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human TNF-alpha Antibody, Clone MT15B15, PF488P and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Human TNF-alpha Antibody, Clone MT15B15, PF488P Catalog #
100-1462 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human TNF-alpha Antibody, Clone MT15B15, PF647P Catalog #
100-1461 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human TNF-alpha Antibody, Clone MT15B15, Biotin Catalog #
100-1463 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human TNF-alpha Antibody, Clone MT15B15, PF488P Catalog #
100-1462 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human TNF-alpha Antibody, Clone MT15B15, PF647P Catalog #
100-1461 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human TNF-alpha Antibody, Clone MT15B15, Biotin Catalog #
100-1463 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
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