产品号 #100-1464_C
Mouse monoclonal IgG1 antibody against human, cynomolgus IL-2
概述
This mouse monoclonal antibody (clone MT8G10) reacts with human interleukin 2 (IL-2). IL-2 is an ~16 kDa cytokine composed of a four-alpha-helix bundle (Arenas-Ramirez et al.), produced primarily by CD4+ T helper (Th) cells and to a lesser degree by CD8+ T cells, natural killer (NK) cells, and NK T cells (Boyman & Sprent). It binds to the IL-2 receptor α (IL-2Rα; CD25), which complexes with IL-2Rꞵ (CD122) and γc (CD132) subunits (Malek & Castro) and leads to the activation of JAK1/3, P13K-AKT, and MAPK signaling pathways (Arenas-Ramirez et al.). IL-2 mediates T cell growth and proliferation, facilitates the differentiation of CD4+ T cells to Th1 and Th2 cells, promotes CD8+ T cell and NK cell cytolytic activity, and drives the development of CD4+FOXP3+ regulatory T cells (Liao et al.).
Target Antigen
IL-2
Alternative Names
IL2, interleukin 2, interleukin-2, lymphokine, T cell growth factor, TCGF
Reactive Species
Human, Other
Conjugation
Biotin, FITC
Host Species
Mouse
Cell Type
NK Cells, T Cells, CD4+, T Cells, CD8+
Species
Human, Other
Application
Flow Cytometry
Area of Interest
Immunology
Clone
MT8G10
Gene ID
3558
Isotype
IgG1
Data Figures
Figure 1. Data for Anti-Human IL-2 Antibody, Clone MT8G10 FITC
(A) Flow cytometry analysis of unstimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-2 Antibody, Clone MT8G10, FITC and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1). (B) Flow cytometry analysis of PMA/ionomycin-stimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-2 Antibody, Clone MT8G10, FITC and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Human IL-2 Antibody, Clone MT8G10, FITC Catalog #
100-1464 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human IL-2 Antibody, Clone MT8G10, Biotin Catalog #
100-1465 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human IL-2 Antibody, Clone MT8G10, FITC Catalog #
100-1464 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human IL-2 Antibody, Clone MT8G10, Biotin Catalog #
100-1465 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Request Pricing
Thank you for your interest in IntestiCult™ Organoid Growth Medium (Human). Please provide us with your contact information and your local representative will contact you with a customized quote. Where appropriate, they can also assist you with a(n):
Estimated delivery time for your area
Product sample or exclusive offer
In-lab demonstration
By submitting this form, you are providing your consent to STEMCELL Technologies Canada Inc. and its subsidiaries and affiliates (“STEMCELL”) to collect and use your information, and send you newsletters and emails in accordance with our
privacy policy. Please contact us with any questions that you may have. You can unsubscribe or change your email preferences at any time.
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
欢迎您关注STEMCELL Technologies的微信公众平台
扫描二维码或搜索微信号STEMCELLTech，即可关注我们的微信平台，第一时间接收丰富的技术资源和最新的活动信息。
如您有任何问题，欢迎发消息给STEMCELLTech微信公众平台，或与我们通过电话/邮件联系：400 885 9050 INFO.CN@STEMCELL.COM。