产品号 #60159_C
Mouse monoclonal IgG1 antibody against human CD298
概述
The LNH-94 antibody reacts with human CD298, the β3 subunit of the Na+/K+ ATPase. The Na+/K+ ATPase is a 42 kDa type II transmembrane protein composed of four catalytic α subunits and three smaller glycosylated non-catalytic β subunits. The Na+/K+ ATPase is important for establishing electrochemical gradients and maintaining normal resting membrane potential by coupling ATP hydrolysis to the active transport of Na+ and K+. The β subunits have been reported to act as chaperones that stabilize the α subunits and occlude K+. CD298 has been used to identify metastatic human cancer cells in mouse xenograft models and has been reported to modulate aspects of immunity, including HIV production, and T cell and B cell activation. CD298 is found on leukocytes, platelets, and most other tissue types.
Subtype
Primary Antibodies
Target Antigen
CD298
Reactive Species
Human
Conjugation
APC, PE
Host Species
Mouse
Cell Type
B Cells, Granulocytes and Subsets, Lymphocytes, Mammary Cells, Monocytes, T Cells
Species
Human
Application
Flow Cytometry
Area of Interest
Cancer, Disease Modeling, Endothelial Cell Biology, Immunology, Transplantation Research
Clone
LNH-94
Gene ID
483
Data Figures
Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD298 Antibody, Clone LNH-94, PE (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE; solid line histogram).
Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD298 Antibody, Clone LNH-94, APC (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (Catalog # 60070AZ; solid line histogram).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Human CD298 Antibody, Clone LNH-94, APC Catalog #
60159AZ Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD298 Antibody, Clone LNH-94, APC Catalog #
60159AZ Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for B Cell Research
Workflow Stages for Granulocyte Research
Workflow Stages for Mammary Epithelial Cell Research
Resources and Publications
Educational Materials (2)
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