产品号 #100-1653_C
组蛋白修饰剂；抑制常染色质组蛋白甲基转移酶1（EHMT1）和2（EHMT2）
总览
使用强效常染色质组蛋白甲基转移酶1（EHMT1；IC50 = 39 nM）和EHMT2（IC50 = 15 nM）抑制剂UNC0224，将人体细胞重编程为多能干细胞。EHMT1和EHMT2能够对组蛋白3第9位赖氨酸残基（H3K9）进行单甲基化、二甲基化和三甲基化修饰，从而调控基因表达（Leenders等，Bioorg Med Chem Lett，2019；Liu等人，J Med Chem，2009)。在胚胎干细胞中，EHMT1和EHMT2可形成异源二聚体以维持H3K9甲基化状态（Shinkai & Tachibana，Genes Dev，2011；Zhang等，Cell Rep，2016)。在多种癌症中，EHMT1和EHMT2的过表达与肿瘤转移、干性维持及治疗抵抗密切相关。通过敲低EHMT1/2抑制H3K9甲基化已被证实具有抗肿瘤效应，可诱导细胞凋亡、减少迁移并抑制肿瘤生长（Nachiyappan等，FEBS J，2022)。
UNC0224已被用于以下研究：
重编程研究
·联合其他小分子化合物将人体细胞重编程为多能干细胞（Guan等，Nature，2022)。
别名
UNC 0224
细胞类型
癌细胞及细胞系，多能干细胞
研究领域
癌症，干细胞生物学
CAS 编号
1197196-48-7
化学式
C26H43N7O2
分子量
485.7 克/摩尔
纯度
≥98%
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
UNC0224 Catalog #
100-1653 Lot #
All Language
English Resources and Publications
Educational Materials (3)
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更多信息
| Molecular Weight | 485.7 g/mol |
|---|---|
| Alternative Names | UNC 0224 |
| Cas Number | 1197196-48-7 |
| Chemical Formula | C26H43N7O2 |
| Purity | ≥ 98% |
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