Troglitazone is a potent and selective activator of peroxisome proliferator-activated receptor-γ (PPARγ) with EC50 = 0.55 and 0.78 µM for human and mouse, respectively. Troglitazone does not inhibit PPARα or PPARδ at up to 10 µM (Willson et al.). Troglitazone causes cell cycle arrest at phase G1, inducing caspase-dependent apoptosis in both HeLa and hepatocellular carcinoma cell lines (Yoshizawa et al.; Chang et al.).
DIFFERENTIATION
· Stimulates adipogenesis in 3T3-L1 cells (Jeong & Yoon).
· Inhibits macrophage differentiation (Chen Y et al.).
METABOLISM
· Exerts potent glucose-lowering effects in insulin-resistant diabetic animals and in non-insulin-dependent (type II) human diabetic subjects (Lee & Olefsky).
CANCER RESEARCH
· Inhibits growth and induces apoptosis in non-small cell lung carcinoma, bladder cancer, cervical cancer, and prostate cancer cells (Chen H-M et al.; Santha et al.; Satoh et al.; Yan et al.).
· Promotes cytostatic effects in MDA-MB-231 and MCF-7 breast cancer cell lines (Berthe et al.)
DIFFERENTIATION
· Stimulates adipogenesis in 3T3-L1 cells (Jeong & Yoon).
· Inhibits macrophage differentiation (Chen Y et al.).
METABOLISM
· Exerts potent glucose-lowering effects in insulin-resistant diabetic animals and in non-insulin-dependent (type II) human diabetic subjects (Lee & Olefsky).
CANCER RESEARCH
· Inhibits growth and induces apoptosis in non-small cell lung carcinoma, bladder cancer, cervical cancer, and prostate cancer cells (Chen H-M et al.; Santha et al.; Satoh et al.; Yan et al.).
· Promotes cytostatic effects in MDA-MB-231 and MCF-7 breast cancer cell lines (Berthe et al.)
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Troglitazone
Catalog #
73892
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Troglitazone
Catalog #
73892
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Mammary Epithelial Cell Research
Workflow Stages for Mesenchymal Stem and Progenitor Cell Research
Resources and Publications
Educational Materials (3)
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