Tauroursodeoxycholic acid is an endogenous hydrophilic bile and exhibits both anti-apoptotic and neuroprotective properties (Keene et al.; Yoon et al.). It protects against cell death by attenuating endoplasmic reticulum stress, inhibiting caspase activation and the production of oxygen radicals, and modulating the unfolded protein response (Vang et al.; Yoon et al.).
DISEASE MODELING
· Decreases both striatal atrophy and apoptosis in a mouse model of Huntington’s disease (Keene et al.).
· Blocks apoptotic events such as Bax translocation to mitochondrial membrane, cytochrome c release, caspase activation, and nuclear fragmentation (Vang et al.).
DISEASE MODELING
· Decreases both striatal atrophy and apoptosis in a mouse model of Huntington’s disease (Keene et al.).
· Blocks apoptotic events such as Bax translocation to mitochondrial membrane, cytochrome c release, caspase activation, and nuclear fragmentation (Vang et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Tauroursodeoxycholic Acid (Sodium Salt)
Catalog #
100-0884
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Tauroursodeoxycholic Acid (Sodium Salt)
Catalog #
100-0884
Lot #
All
Language
English
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