SAHA (suberoylanilide hydroxamic acid) is a potent inhibitor of class I and class II histone deacetylases (HDACs). This compound inhibits the activities of HDAC1 and HDAC3 (IC50 = 10 nM and 20 nM, respectively; Richon et al.). SAHA exhibits antiproliferative properties and can cause cell cycle arrest at G1 (Marks & Breslow).
REPROGRAMMING
· Improves reprogramming efficiency from human and mouse somatic to induced pluripotent stem cells (Huangfu et al.).
CANCER RESEARCH
· Downregulates homologous recombination and leads to apoptosis in ovarian cancer cells when used in combination with olaparib (Konstantinopoulos et al.).
· SAHA downregulates Nanog expression, which leads to proliferation inhibition in head and neck cancer stem cells (Kumar et al.).
REPROGRAMMING
· Improves reprogramming efficiency from human and mouse somatic to induced pluripotent stem cells (Huangfu et al.).
CANCER RESEARCH
· Downregulates homologous recombination and leads to apoptosis in ovarian cancer cells when used in combination with olaparib (Konstantinopoulos et al.).
· SAHA downregulates Nanog expression, which leads to proliferation inhibition in head and neck cancer stem cells (Kumar et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
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Lot #
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Document Type
Product Information Sheet
Product Name
SAHA
Catalog #
73902
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Human Pluripotent Stem Cell Research
Workflow Stages for Mouse Pluripotent Stem Cell Research
Resources and Publications
Educational Materials (3)
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