产品号 #73902_C
表观遗传修饰词;抑制HDAC1和HDAC3
概述
SAHA（亚甲基苯胺羟肟酸）是一类和二类组蛋白去乙酰化酶（hdac）的有效抑制剂。该化合物抑制HDAC1和HDAC3活性（IC50分别为10 nM和20 nM）；Richon等人)。SAHA具有抗增殖特性，可导致细胞周期阻滞于G1 （Marks & Breslow）。
重新编程
·提高人类和小鼠体细胞到诱导多能干细胞的重编程效率（Huangfu等）。
癌症研究
·与奥拉帕尼联合使用时，下调同源重组并导致卵巢癌细胞凋亡（Konstantinopoulos等人）。
·SAHA下调Nanog表达，导致头颈癌干细胞增殖抑制（Kumar等）。
Cell Type
Cancer Cells and Cell Lines, Pluripotent Stem Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Reprogramming
Area of Interest
Cancer, Disease Modeling, Stem Cell Biology
CAS Number
149647-78-9
Chemical Formula
C₁₄H₂₀N
Purity
≥ 98%
Pathway
Epigenetic
Target
HDAC
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
更多信息
| Species | Human, Mouse, Non-Human Primate, Other, Rat |
|---|---|
| Cas Number | 149647-78-9 |
| Chemical Formula | C₁₄H₂₀N |
| Purity | ≥ 98% |
| Target | HDAC |
| Pathway | Epigenetic |
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
