产品号 #73392_C
表观遗传修饰剂；抑制 DNA 甲基转移酶 (DNMT)
总览
重编程刺激化合物(RSC)-133是一种吲哚衍生物，可特异性抑制 DNA 甲基转移酶 DNMT1（Lee 等）。
重编程
·与重编程因子 OCT4、SOX2、KLF4 和 c-MYC 一起使用时，可提高人类包皮成纤维细胞重编程为诱导性多能干细胞的动力学和效率（Lee等）。
维持与自我更新
·在无条件培养基(unconditioned medium)中，有助于维持人多能干细胞的自我更新状态（Lee等）。
细胞类型
多能干细胞
种属
人，小鼠，非人灵长类，其它细胞系，大鼠
应用
培养，重编程
研究领域
干细胞生物学
CAS 编号
1418131-46-0
化学式
C₁₈H₁₅N₃O₂
纯度
≥ 95 %
通路
表观遗传学
靶点
DNMT
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (2)
Publications (1)
A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells. Angewandte Chemie (International ed. in English) 2012
Abstract
Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).
更多信息
| Species | Human, Mouse, Non-Human Primate, Other, Rat |
|---|---|
| Cas Number | 1418131-46-0 |
| Chemical Formula | C₁₈H₁₅N₃O₂ |
| Purity | ≥ 95% |
| Target | DNMT |
| Pathway | Epigenetic |
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
