RS-1 is an enhancer of RAD51, an enzyme that assists in the homology-directed repair (HDR) pathway of DNA double-strand breaks, and is reported to function by stabilizing the active form of RAD51 and by enhancing recombinogenic activity of the enzyme (Jayathilaka et al.). Via this mechanism, RS-1 can stimulate HDR, thereby enhancing precise HDR-dependent CRISPR-Cas9 genome editing in some cell lines (Pinder et al.; Song et al.).
GENOME EDITING
· Promotes HDR, which is reported to enhance knock-in efficiency of CRISPR-Cas9 genome editing (Pinder et al.; Song et al.); however, these effects are cell type-specific and context-dependent (Xie et al.; Zhang et al.).
CANCER RESEARCH
· Stimulates the DNA-binding activity of RAD51 to promote cancer cell death and induce anti-tumor responses in a mouse xenograft tumor model (Mason et al.).
GENOME EDITING
· Promotes HDR, which is reported to enhance knock-in efficiency of CRISPR-Cas9 genome editing (Pinder et al.; Song et al.); however, these effects are cell type-specific and context-dependent (Xie et al.; Zhang et al.).
CANCER RESEARCH
· Stimulates the DNA-binding activity of RAD51 to promote cancer cell death and induce anti-tumor responses in a mouse xenograft tumor model (Mason et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
RS-1
Catalog #
74094, 74092
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
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