产品号 #78210_C
促血小板生成素
血小板生成素(TPO)是体外和体内巨核细胞生成和血小板生成的关键调节因子。TPO刺激巨核细胞的增殖和成熟,并在调节体内循环血小板水平方面发挥重要作用(Bartley等;de Sauvage等人;福斯特等人;Sohma等人)。TPO还能促进造血干细胞和原始多系祖细胞的存活、自我更新和扩增。它通常与其他细胞因子如干细胞因子(SCF)和Flt3/Flk-2配体一起用于促进培养的原始造血细胞的扩增(Hitchcock & Kaushansky)。TPO受体c-Mpl在巨核形成的所有阶段都有表达,从造血干细胞和祖细胞到成熟血小板(Ng等)。
Subtype
Cytokines
Cell Type
Hematopoietic Stem and Progenitor Cells, Mesoderm, PSC-Derived, Pluripotent Stem Cells
Species
Human
Area of Interest
Stem Cell Biology
Purity
≥ 90%
The biological activity of Human Recombinant TPO was tested by its ability to promote the proliferation of MO7e cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 10.2 ng/mL.
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
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Species | Human |
---|---|
Purity | ≥ 90% |
人CD34+造血细胞扩增的无血清培养补充物
人粒细胞扩增和分化的无血清培养补充物
人巨核细胞扩增的无血清培养补充物
人造血细胞扩增的无血清培养补充物
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