Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a reversible, highly potent activator of protein kinase C (PKC), including Group A and Group B isoforms (Blumberg). PMA activates PKC isoforms through the binding of the C1 domain (Hurley et al.). PMA can also activate certain mitogen-activated protein (MAP) kinase pathways through PKC (Adams & Parker).
DIFFERENTIATION
· Stimulates cardiac differentiation of mesenchymal stem cells (Seo et al.).
· Promotes hematopoietic differentiation (Clemens et al.).
IMMUNOLOGY
· Stimulates differentiation of IL-15-stimulated lamina propria CD4+ T cells into CXCR5+CD4+ cells when used together with ionomicin (Sarra et al.).
CANCER RESEARCH
· In combination with AS101, it shows anti-leukemic activity and stimulates human leukemia cell lines to differentiate into macrophage-like cells (Glesne & Huberman; Hayun et al.).
DIFFERENTIATION
· Stimulates cardiac differentiation of mesenchymal stem cells (Seo et al.).
· Promotes hematopoietic differentiation (Clemens et al.).
IMMUNOLOGY
· Stimulates differentiation of IL-15-stimulated lamina propria CD4+ T cells into CXCR5+CD4+ cells when used together with ionomicin (Sarra et al.).
CANCER RESEARCH
· In combination with AS101, it shows anti-leukemic activity and stimulates human leukemia cell lines to differentiate into macrophage-like cells (Glesne & Huberman; Hayun et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Phorbol 12-myristate 13-acetate
Catalog #
74044, 74042
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Phorbol 12-myristate 13-acetate
Catalog #
74044, 74042
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Mesenchymal Stem and Progenitor Cell Research
Workflow Stages for T Cell Research
Workflow Stages for Monocyte Research
Resources and Publications
Educational Materials (4)
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