产品号 #74082_C
NHEJ通路抑制剂；抑制DNA依赖性蛋白激酶（DNA-PK）
总览
NU7441是DNA依赖性蛋白激酶（DNA- PK）的抑制剂，DNA- PK是一种参与非同源末端连接（NHEJ） DNA修复通路的酶。它对DNA-PK具有高度选择性，IC₅₀为14 nM （Leahy et al.）。
基因组编辑
·降低了CRISPR-Cas9基因组编辑中NHEJ的频率，提高了同源定向修复（HDR）的效率（Robert et al.）。
癌症研究
·通过抑制DNA- PK活性和延迟双链断裂的修复，增强人癌细胞系对DNA双链断裂诱导疗法（化疗或放疗）的敏感性（Ciszewski et al.; Shaheen et al.; Yang et al.; Zhao et al.)。
细胞类型
癌细胞及细胞系，前列腺细胞
种属
人，小鼠，非人灵长类，其它细胞系，大鼠
应用
基因组编辑
研究领域
癌症
CAS 编号
503468-95-9
化学式
C₂₅H₁₉NO₃S
纯度
≥98%
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
NU7441 Catalog #
74082, 74084 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
NU7441 Catalog #
74082, 74084 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Mammary Epithelial Cell Research
Workflow Stages for Genome Editing
Resources and Publications
Educational Materials (3)
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更多信息
| Species | Human, Mouse, Non-Human Primate, Other, Rat |
|---|---|
| Cas Number | 503468-95-9 |
| Chemical Formula | C₂₅H₁₉NO₃S |
| Purity | ≥ 98% |
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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