产品号 #78122_C
tnf相关的凋亡诱导配体
概述
TRAIL （TNF相关凋亡诱导配体）属于肿瘤坏死因子（TNF）超家族，与启动细胞凋亡有关。TRAIL有四个主要受体：两个死亡受体DR4和DR5，两个诱饵受体DcR1和DcR2。TRAIL与死亡受体结合，募集fas相关死亡结构域（FADD）并激活caspase 8和10，最终导致细胞凋亡(Pitti等人；Wiley等人；Zauli & Secchiero)。研究表明，缺乏TRAIL表达的小鼠在胸腺细胞凋亡和负选择方面存在缺陷，这些小鼠对自身免疫性疾病的易感性增加（Lamhamedi-Cherradi等）。
Subtype
Cytokines
Alternative Names
TL2, TNF-related apoptosis-inducing ligand, TNFSF10
Cell Type
T Cells
Species
Mouse
Area of Interest
Immunology
Molecular Weight
20 kDa
Purity
≥ 98%
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
更多信息
| Molecular Weight | 20 kDa |
|---|---|
| Species | Mouse |
| Alternative Names | TL2, TNF-related apoptosis-inducing ligand, TNFSF10 |
| Purity | ≥ 98% |
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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
