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小鼠重组EGF

表皮生长因子
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产品号 #78016_C

表皮生长因子

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概述

表皮生长因子（Epidermal growth factor， EGF）是EGF蛋白家族的创始成员，其特点是与各种EGF受体（egfr）高亲和力结合，并产生有丝分裂反应（Carpenter & Cohen）。EGF促进EGFR二聚化，激活下游通路，包括PI3K、ERK1/2、JAK/STAT、β-catenin和钙信号。EGF由与肠道相关的唾液腺和布鲁纳腺分泌，存在于多种体液中，并刺激啮齿动物和新生儿肠道中的细胞增殖和分化（Wright等）。EGF可刺激小鼠胚胎干细胞增殖或诱导A431细胞终末分化/生长抑制（Heo等）。

Subtype
Cytokines, Growth Factors
 
Cell Type
Brain Tumor Stem Cells, Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Mesenchymal Stem and Progenitor Cells, Mesoderm, PSC-Derived, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons, Pluripotent Stem Cells, Prostate Cells
 
Species
Mouse
 
Area of Interest
Cancer, Epithelial Cell Biology, Neuroscience, Stem Cell Biology
 
Purity
≥ 95 %
 

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Data Figures

(A) The biological activity of Mouse Recombinant EGF was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.1 ng/mL. (B) 5 μg of Mouse Recombinant EGF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant EGF has a predicted molecular mass of 6.2 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant EGF
Catalog #
78016.1, 78016
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant EGF
Catalog #
78016.1, 78016
Lot #
All
Language
English

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Species Mouse
Purity ≥ 95 %
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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