产品号 #74182_C
抑制NEDD8-活化酶
总览
MLN4924 通过直接作用于对 cullin-RING 连接酶 (CRL) 活性至关重要的 NEDD8 激活酶来抑制 cullin neddylation (Nawrocki et al.)。CRL 的成分在人癌症中经常上调 (Zhao & Sun)，据报道 MLN4924 可抑制小鼠体内人类肿瘤异种移植瘤的生长（Soucy et al.）。
基因组编辑
·据报道，与其他小分子（“CRISPY” 混合物）结合，MLN4924 可提高人多能干细胞中 CRISPR-Cas9 基因组编辑的精确度（Riesenberg & Maricic）。
癌症研究
·通过阻断 NAE 和蛋白酶体，MLN4924 与硼替佐米联合使用可抑制 AKT 和 mTOR，并诱导多发性骨髓瘤细胞系细胞凋亡（Gu et al.）。
细胞类型
癌细胞及细胞系，髓系细胞，多能干细胞
种属
人，小鼠，非人灵长类，其它细胞系，大鼠
应用
基因组编辑
研究领域
癌症，干细胞生物学
CAS 编号
905579-51-3
化学式
C₂₁H₂₅N₅O₄S
纯度
≥98%
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
MLN4924 Catalog #
74184, 74182 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
MLN4924 Catalog #
74184, 74182 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Human Pluripotent Stem Cell Research
Workflow Stages for Genome Editing
Resources and Publications
Educational Materials (3)
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更多信息
| Species | Human, Mouse, Non-Human Primate, Other, Rat |
|---|---|
| Cas Number | 905579-51-3 |
| Chemical Formula | C₂₁H₂₅N₅O₄S |
| Purity | ≥ 98% |
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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