Inhibit cancer cell growth by selectively inhibiting poly ADP ribose polymerase (PARP) with MK-4827 (Tosylate). With a high affinity for both PARP1 and PARP2 (IC50 = 3.8 and 2.1 nM), MK-4827 demonstrates antiproliferative effects on cancer cells with BRCA1 or BRCA2 mutations (Jones et al.; Yuan et al.). PARPs are a family of enzymes that repair DNA breaks through the base excision repair (BER); MK-4827 inhibits this activity, leading to DNA damage and cell death (Yuan et al.).
MK-4827 (Tosylate) has been used for:
CANCER RESEARCH
· Antiproliferative effect against MDA-MB-436 and HeLa cells expressing BRCA1 mutation (Jones et al., 2009).
· Inhibits growth in human MDA-MB-436 tumor cells with BRCA 1 mutant (Jones et al., 2015).
MK-4827 (Tosylate) has been used for:
CANCER RESEARCH
· Antiproliferative effect against MDA-MB-436 and HeLa cells expressing BRCA1 mutation (Jones et al., 2009).
· Inhibits growth in human MDA-MB-436 tumor cells with BRCA 1 mutant (Jones et al., 2015).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
MK-4827 (Tosylate)
Catalog #
100-1160
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
MK-4827 (Tosylate)
Catalog #
100-1160
Lot #
All
Language
English
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Resources and Publications
Educational Materials (3)
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