Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist that stimulates the production of dopamine in the brain (Parsons et al.). NMDA receptor is a calcium-permeable ion channel found in neurons and regulated by its ligands glutamate and glycine (Song et al.). NMDA receptor signaling is involved with plasticity, cell survival, and cell death. Hyperactivity of these receptors can result in neuron loss and may contribute to neurodegenerative diseases (Parsons & Raymond; Song et al.). Memantine is used to treat patients with Parkinson's disease and Alzheimer's disease (Meisner et al.; Parsons et al.).
DISEASE MODELING
· Upregulates the expression of brain-derived neurotrophic factor (BDNF) and prevents the onset of dopamine deficiency in macaques infected with simian immunodeficiency virus (SIV; Meisner et al.).
DISEASE MODELING
· Upregulates the expression of brain-derived neurotrophic factor (BDNF) and prevents the onset of dopamine deficiency in macaques infected with simian immunodeficiency virus (SIV; Meisner et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Memantine (Hydrochloride)
Catalog #
100-0894
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Memantine (Hydrochloride)
Catalog #
100-0894
Lot #
All
Language
English
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