KU0060648 is an ATP-competitive and highly potent inhibitor of DNA-dependent protein kinase (DNA-PK), with IC₅₀ values of 19 nM in MCF7 human breast cancer cells and 170 nM in SW620 human colon cancer cells. KU0060648 also inhibits phosphoinositide 3-kinase (PI3K) with IC₅₀ values of 39 nM in MCF7 cells and > 10 µM in SW620 cells, which suggests a cell-dependent mechanism (Munck et al.).
GENOME EDITING
· Reduces the frequency of non-homologous end joining (NHEJ) and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.).
CANCER RESEARCH
· Inhibits tumor growth and sensitizes human cancer cells to DNA double-strand-break (DSB)-inducing therapies (chemo- or radio-therapy) by inhibiting both DNA-PK and PI3K and preventing the execution of DSB repair (Chen et al.; Dietlein et al.; Munck et al.).
GENOME EDITING
· Reduces the frequency of non-homologous end joining (NHEJ) and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.).
CANCER RESEARCH
· Inhibits tumor growth and sensitizes human cancer cells to DNA double-strand-break (DSB)-inducing therapies (chemo- or radio-therapy) by inhibiting both DNA-PK and PI3K and preventing the execution of DSB repair (Chen et al.; Dietlein et al.; Munck et al.).
未找到
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
KU0060648
Catalog #
74062
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Mammary Epithelial Cell Research
Workflow Stages for Genome Editing
Resources and Publications
Educational Materials (3)
Request Pricing
Thank you for your interest in IntestiCult™ Organoid Growth Medium (Human). Please provide us with your contact information and your local representative will contact you with a customized quote. Where appropriate, they can also assist you with a(n):
Estimated delivery time for your area
Product sample or exclusive offer
In-lab demonstration
By submitting this form, you are providing your consent to STEMCELL Technologies Canada Inc. and its subsidiaries and affiliates (“STEMCELL”) to collect and use your information, and send you newsletters and emails in accordance with our
privacy policy. Please contact us with any questions that you may have. You can unsubscribe or change your email preferences at any time.
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
欢迎您关注STEMCELL Technologies的微信公众平台
扫描二维码或搜索微信号STEMCELLTech，即可关注我们的微信平台，第一时间接收丰富的技术资源和最新的活动信息。
如您有任何问题，欢迎发消息给STEMCELLTech微信公众平台，或与我们通过电话/邮件联系：400 885 9050 INFO.CN@STEMCELL.COM。