Janus Associated Kinase (JAK) Inhibitor I is a pyridine-containing tetracycle that disrupts JAK activity by interacting with the ATP binding domain. This inhibitor inhibits mouse JAK3 with Ki = 5 nM, JAK family members TYK2 and JAK2 with IC50 = 1 nM, and mouse JAK1 with IC50 = 15 nM, while showing weaker inhibition of other kinases (Thompson et al.).
REPROGRAMMING
· Inhibits the generation of mouse induced pluripotent stem cells (Efe et al.; Kim et al.).
IMMUNOLOGY
· Inhibits anti-viral response associated with JAK/STAT pathway activation (Xu et al.).
REPROGRAMMING
· Inhibits the generation of mouse induced pluripotent stem cells (Efe et al.; Kim et al.).
IMMUNOLOGY
· Inhibits anti-viral response associated with JAK/STAT pathway activation (Xu et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
JAK Inhibitor I
Catalog #
74024
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
JAK Inhibitor I
Catalog #
74024
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Mouse Pluripotent Stem Cell Research
Resources and Publications
Educational Materials (3)
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