产品号 #74022_C
JAK/STAT通路抑制剂;抑制JAK1、JAK2和JAK3
Janus Associated Kinase (JAK) 抑制剂I是一种含吡啶的四环化合物,通过与ATP结合域相互作用破坏JAK活性。该抑制剂对Ki = 5 nM的小鼠JAK3、IC₅₀ = 1 nM的JAK家族成员TYK2和JAK2以及IC₅₀ = 15 nM的小鼠JAK1均有抑制作用,而对其他激酶的抑制作用较弱(Thompson et al.)。
重编程
·抑制小鼠诱导多能干细胞的生成(Efe et al.; Kim et al.)。
免疫学
·抑制与JAK/STAT通路激活相关的抗病毒反应(Xu et al.)。
细胞类型
多能干细胞
种属
人,小鼠,非人灵长类,其它细胞系,大鼠
应用
培养,重编程
研究领域
干细胞生物学
CAS 编号
457081-03-7
化学式
C₁₈H₁₆FN
₃O
"
纯度
≥98%
通路
JAK/STAT
靶点
JAK1,JAK2,JAK3
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
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Species | Human, Mouse, Non-Human Primate, Other, Rat |
---|---|
Cas Number | 457081-03-7 |
Chemical Formula | C₁₈H₁₆FN ₃O " |
Purity | ≥ 98% |
Target | JAK1, JAK2, JAK3 |
Pathway | JAK/STAT |
酪氨酸激酶抑制剂;抑制EGFR、HER2、JAK2、JAK3和STAT5a/b
JAK/STAT通路抑制剂;抑制JAK1和JAK2
JAK/STAT通路抑制剂;抑制JAK2
JAK/STAT通路抑制剂;抑制STAT5
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