JAK抑制剂I

JAK/STAT通路抑制剂;抑制JAK1、JAK2和JAK3

产品号 #(选择产品)

产品号 #74022_C

JAK/STAT通路抑制剂;抑制JAK1、JAK2和JAK3

总览

Janus Associated Kinase (JAK) 抑制剂I是一种含吡啶的四环化合物,通过与ATP结合域相互作用破坏JAK活性。该抑制剂对Ki = 5 nM的小鼠JAK3、IC₅₀ = 1 nM的JAK家族成员TYK2和JAK2以及IC₅₀ = 15 nM的小鼠JAK1均有抑制作用,而对其他激酶的抑制作用较弱(Thompson et al.)。


重编程

·抑制小鼠诱导多能干细胞的生成(Efe et al.; Kim et al.)。


免疫学

·抑制与JAK/STAT通路激活相关的抗病毒反应(Xu et al.)。

细胞类型
多能干细胞
 
种属
人,小鼠,非人灵长类,其它细胞系,大鼠
 
应用
培养,重编程
 
研究领域
干细胞生物学
 
CAS 编号
457081-03-7
 
化学式
C₁₈H₁₆FN ₃O "
 
纯度
≥98%
 
通路
JAK/STAT
 
靶点
JAK1,JAK2,JAK3
 

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
JAK Inhibitor I
Catalog #
74024
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
JAK Inhibitor I
Catalog #
74024
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

更多信息

更多信息
Species Human, Mouse, Non-Human Primate, Other, Rat
Cas Number 457081-03-7
Chemical Formula C₁₈H₁₆FN ₃O "
Purity ≥ 98%
Target JAK1, JAK2, JAK3
Pathway JAK/STAT
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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