Inducer of definitive endoderm 2 (IDE2) induces differentiation of mouse or human pluripotent stem cells (PSCs) by activating SMAD2 phosphorylation and NODAL expression (Borowiak et al.). At EC₅₀ = 223nM, SOX17 expression was induced in mouse ES cells.
DIFFERENTIATION
· Induces definitive endoderm from mouse or human ES cells in the absence of Activin A, NODAL, or feeder cells (Borowiak et al.).
DIFFERENTIATION
· Induces definitive endoderm from mouse or human ES cells in the absence of Activin A, NODAL, or feeder cells (Borowiak et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
IDE2
Catalog #
72524, 72522
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Human Pluripotent Stem Cell Research
Workflow Stages for hPSC-Derived Endoderm Cell Research
Workflow Stages for Mouse Pluripotent Stem Cell Research
Resources and Publications
Educational Materials (2)
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