产品号 #78099_C
Regulated upon activation, normal T cell expressed and secreted
概述
RANTES (regulated upon activation, normal T cell expressed and secreted), also known as CCL5, is a member of the CC family of chemokines and is able to recruit leukocytes to sites of inflammation (Schall et al.). RANTES is secreted by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells (Aldinucci & Colombatti; Soria & Ben-Baruch). This chemokine exerts its effect by interacting with the chemokine receptors CCR1, CCR3, CCR4, and CCR5. RANTES plays an active role in recruiting a variety of leukocytes into inflammatory sites, including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and IFN-γ, RANTES also induces the activation and proliferation of NK cells to generate CC chemokine-activated killer cells, which are highly cytolytic (Lv et al.; Maghazachi et al.). It has been shown that RANTES produced by CD8+ T cells inhibits HIV infection of primary human peripheral blood mononuclear cells (Appay & Rowland-Jones; Cocchi et al.).
Subtype
Cytokines
Cell Type
B Cells, Dendritic Cells, Mesenchymal Stem and Progenitor Cells, Monocytes, NK Cells, Other, T Cells, T Cells, CD4+, T Cells, CD8+
Species
Human
Area of Interest
Immunology, Stem Cell Biology
Purity
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant RANTES (CCL5) was tested by its ability to induce chemotaxis of THP-1 cells. Cell migration was measured after 45 min using a fluorometric assay method. Increase in migration over basal level was seen starting at 10 ng/mL. (B) 1 μg of Human Recombinant RANTES (CCL5) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant RANTES (CCL5) has a predicted molecular mass of 7.9 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant RANTES (CCL5) Catalog #
78099, 78099.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant RANTES (CCL5) Catalog #
78099, 78099.1 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Granulocyte Research
Workflow Stages for Monocyte Research
Resources and Publications
Educational Materials (3)
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