重组人催乳素

催乳素

产品号 #(选择产品)

产品号 #78098_C

催乳素

总览

催乳素是一种由垂体分泌的肽激素,具有刺激、启动和维持泌乳的作用。催乳素还参与调控乳腺发育和免疫系统,并在代谢和行为改变中发挥重要作用(Bernichtein et al.)。催乳素的作用由催乳素受体(PRLR)介导,该受体是一种单链跨膜蛋白,包含胞外区、跨膜区和胞内区。研究表明,高至正常循环水平的催乳素会增加乳腺癌的风险,多巴胺受体的激动剂被认为可能在治疗中有效(Bernichtein et al.)。据报道,多发性硬化症患者的催乳素水平较高,这促进了B细胞的自身反应性(Correale et al.)。研究发现,小鼠骨髓移植后给予重组催乳素可促进免疫和髓系细胞重建(Sun et al.)。

亚型
细胞因子
 
别名
Luteotropin,促黄体生成素,催乳素,PRL
 
细胞类型
脂肪细胞,淋巴细胞,乳腺细胞,神经干/祖细胞,神经元
 
种属

 
研究领域
免疫,代谢,神经科学,干细胞生物学
 
分子量
23 千道尔顿
 
纯度
≥ 95 %
 

Data Figures

(A) The biological activity of Human Recombinant Prolactin was tested by its ability to promote the proliferation of NB2-11 cells. Cell proliferation was measured after 66 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.02 ng/mL. (B) 1 μg of Human Recombinant Prolactin was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Prolactin has a predicted molecular mass of 23 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78098.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78098.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Resources and Publications

Educational Materials (2)

更多信息

更多信息
Molecular Weight 23 kDa
Species Human
Alternative Names Luteotropin, Luteotropic hormone, Mammotropin, PRL
Purity ≥ 95%
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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