产品号 #78098_C
催乳素
催乳素是一种由垂体分泌的肽激素,具有刺激、启动和维持泌乳的作用。催乳素还参与调控乳腺发育和免疫系统,并在代谢和行为改变中发挥重要作用(Bernichtein et al.)。催乳素的作用由催乳素受体(PRLR)介导,该受体是一种单链跨膜蛋白,包含胞外区、跨膜区和胞内区。研究表明,高至正常循环水平的催乳素会增加乳腺癌的风险,多巴胺受体的激动剂被认为可能在治疗中有效(Bernichtein et al.)。据报道,多发性硬化症患者的催乳素水平较高,这促进了B细胞的自身反应性(Correale et al.)。研究发现,小鼠骨髓移植后给予重组催乳素可促进免疫和髓系细胞重建(Sun et al.)。
亚型
细胞因子
别名
Luteotropin,促黄体生成素,催乳素,PRL
细胞类型
脂肪细胞,淋巴细胞,乳腺细胞,神经干/祖细胞,神经元
种属
人
研究领域
免疫,代谢,神经科学,干细胞生物学
分子量
23 千道尔顿
纯度
≥ 95 %
(A) The biological activity of Human Recombinant Prolactin was tested by its ability to promote the proliferation of NB2-11 cells. Cell proliferation was measured after 66 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.02 ng/mL. (B) 1 μg of Human Recombinant Prolactin was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Prolactin has a predicted molecular mass of 23 kDa.
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Molecular Weight | 23 kDa |
---|---|
Species | Human |
Alternative Names | Luteotropin, Luteotropic hormone, Mammotropin, PRL |
Purity | ≥ 95% |
Serum-free medium for the differentiation of human ES and iPS cells to pancreatic progenitor cells
用于人乳腺球和肿瘤球的培养
小鼠和大鼠神经干祖细胞培养的基础培养基
成分明确、无血清、无异种成分的多能干细胞培养基
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