产品号 #78098_C
Prolactin
概述
Prolactin is a peptide hormone of pituitary origin and is well known for the stimulation, initiation, and maintenance of lactation. Prolactin is also known to regulate mammary gland development and immune system, and has an essential role in metabolism and behavioral modification (Bernichtein et al.). Prolactin actions are mediated by the prolactin receptor (PRLR), which is a single-chain transmembrane protein composed of an extracellular, transmembrane, and intracellular domain. It has also been indicated that high to normal circulating levels of prolactin increase breast cancer risk, and dopamine agonists have been suggested to be effective for treatment (Bernichtein et al.). Prolactin levels have been reported to be higher in multiple sclerosis patients, which promotes B cell autoreactivity (Correale et al.). It has been shown that administration of recombinant prolactin after bone marrow transplantation in mice promotes immune and myeloid reconstitution (Sun et al.).
Subtype
Cytokines
Alternative Names
Luteotropin, Luteotropic hormone, Mammotropin, PRL
Cell Type
Adipocytes, Lymphocytes, Mammary Cells, Neural Stem and Progenitor Cells, Neurons
Species
Human
Area of Interest
Immunology, Metabolism, Neuroscience, Stem Cell Biology
Molecular Weight
23 kDa
Purity
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant Prolactin was tested by its ability to promote the proliferation of NB2-11 cells. Cell proliferation was measured after 66 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.02 ng/mL. (B) 1 μg of Human Recombinant Prolactin was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Prolactin has a predicted molecular mass of 23 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant Prolactin Catalog #
78098.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant Prolactin Catalog #
78098.1 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Total Lymphocyte Research
Resources and Publications
Educational Materials (2)
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