产品号 #100-1296_C
Osteopontin, His tag
概述
A member of the SIBLING family of glycoproteins (Rangaswami et al.), Osteopontin (OPN) functions as T-helper 1 cytokine, and plays an important role in cell signaling, migration, and activation (Weber et al., 2002). Osteopontin has been shown to regulate inflammation both in vitro and in vivo (Agnholt et al.; Kiefer et al.), and has been implicated in the pathophysiology of numerous cancers, including prostate (Thalmann et al.), lung (Chambers et al.), ovarian (Kim et al.), and breast etiologies (Weber et al., 2015). In humans, OPN is initially secreted as a 317 amino acid protein which is subject to tissue-specific post-translational modifications by glycosylation, phosphorylation, and transglutamination (Kazanecki et al.; Sodek et al.). This protein product contains a His-residue tag at the amino end of the polypeptide chain. For consistency and reproducibility across your applications, Osteopontin from STEMCELL comes lyophilized with ≥ 92% purity, and endotoxin levels are verified to be ≤ 1.0 EU/μg protein.
Subtype
Cytokines
Alternative Names
BNSP, BSPI, ETA-1, OPN, SPP1
Species
Human
Area of Interest
Metabolism
Purity
≥ 92%
Data Figures
Human Recombinant Osteopontin was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Osteopontin has a predicted molecular mass of 20.64 kDa but an apparent molecular mass of 35 kDa due to glycosylation.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant Osteopontin Catalog #
100-1296 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant Osteopontin Catalog #
100-1296 Lot #
All Language
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