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人重组IL-21

白细胞介素21，不含动物成分
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产品号 #78193_C

白细胞介素21，不含动物成分

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概述

白细胞介素21 （IL-21）是一种多效性细胞因子，由四个α-螺旋束组成，主要由自然杀伤T细胞（NKT）、T滤泡辅助细胞（Tfh）和Th17细胞产生（Spolski & Leonard 2008）。IL-21信号通过IL-21受体（IL-21R）的异源二聚体和il - 2rg编码的常见细胞因子受体γ链(Parrish-Novak et al.；Ozaki K et al. 2000)，并利用JAK/STAT、MAPK和PI3K通路（Spolski & Leonard 2014）。IL-21已被证明在调节免疫球蛋白的产生和促炎Th17细胞群的分化中起关键作用(Ozaki等人，2002；Nurieva等人)。此外，IL-21特异性地维持CD8+ T细胞效应活性，并在慢性病毒感染期间提供CD4+ T细胞帮助的机制（Elsaesser等）。IL-21信号也被发现对NOD小鼠1型糖尿病的发展至关重要（Sutherland等人），并通过调节性B细胞控制T细胞自身免疫（Yoshizaki等人）。本产品不含动物成分。

Subtype
Cytokines
 
Alternative Names

Interleukin-21, Za11


 
Cell Type
Mesenchymal Stem and Progenitor Cells, NK Cells, T Cells, T Cells, CD4+, T Cells, CD8+, T Cells, Other Subsets
 
Species
Human
 
Area of Interest
Immunology, Stem Cell Biology
 
Formulation Category
Animal Component-Free
 
Purity
≥ 97%
 
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Data Figures

Biological Activity and Molecular Mass of Human Recombinant IL-21, ACF

Figure 1. Biological Activity and Molecular Mass of Human Recombinant IL-21, ACF

(A) The biological activity of Human Recombinant IL-21, ACF was tested by its ability to promote the proliferation of B9 cells. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is ≤ 5 ng/mL.

(B) 1 μg of Human Recombinant IL-21, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-21, ACF has a predicted molecular mass of 15.4 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-21, ACF
Catalog #
78193.1, 78193.2, 78193
Lot #
For 78193: Lot 1000121454 or higher | For 78193.1 & 78193.2: All
Language
English
Document Type
Product Information Sheet 1
Product Name
Human Recombinant IL-21, ACF
Catalog #
78193
Lot #
For 78193: Lot 1000121453 or lower
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-21, ACF
Catalog #
78193.1, 78193.2, 78193
Lot #
All
Language
English

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更多信息
Species Human
Formulation Category Animal Component-Free
Alternative Names Interleukin-21, Za11
Purity ≥ 97%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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