产品号 #78112_C
生长调节致癌基因β
GRO(生长调节致癌基因)- β也称为CXCL2是CXC家族的一员。在组织损伤和微生物感染后的中性粒细胞和嗜碱性粒细胞的募集和激活中起着重要的作用。GRO - β和GRO - γ与GRO - α密切相关,氨基酸序列同源性分别为90%和86%。受体结合研究表明,GRO - α、- β和- γ主要通过G蛋白偶联受体CXCR1和CXCR2发挥功能(Ahuja & Murphy)。GRO - β在上皮细胞、单核细胞、成纤维细胞和黑素细胞中表达,并在炎症、上皮化和血管生成过程中表达上调,例如在人烧伤伤口愈合过程中(Zaja-Milatovic & Richmond)。GRO - β也刺激某些人黑色素瘤细胞的有丝分裂(Unemori et al.)。
亚型
细胞因子
别名
CXCL2;GRO2;生长调节蛋白;巨噬细胞炎症蛋白-2α;黑色素瘤生长刺激活性;MGSAβ;MIP-2α
细胞类型
癌细胞及细胞系,内皮细胞,粒细胞及其亚群
种属
人
研究领域
血管生成细胞研究,癌症,上皮细胞研究,免疫
分子量
7.9 千道尔顿
纯度
≥ 95 %
(A) The biological activity of Human Recombinant GRO-beta (CXCL2) was tested by its ability to mobilize Ca2+ in CHO-K1/Gα15/hCXCR2 cells (human Gα15 and human CXCR2 stably expressed in CHO-K1 cells). Ca2+ mobilization was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which Ca2+ mobilization is at 50% of maximum. The EC50 in the above example is less than 0.2 μg/mL. (B) 2 μg of Human Recombinant GRO-beta (CXCL2) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
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Molecular Weight | 7.9 kDa |
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Species | Human |
Alternative Names | CXCL2, GRO2, Growth regulated protein, Macrophage inflammatory protein-2α, Melanoma growth stimulatory activity, MGSAβ, MIP-2α |
Purity | ≥ 95% |
免疫磁珠负选试剂盒
直接从全血中免疫磁珠分选中性粒细胞
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