产品号 #78112_C
Growth-regulated oncogene beta
概述
GRO (growth-regulated oncogene)-beta or CXCL2 is a member of the CXC family, which plays an integral role in recruitment and activation of neutrophils and basophils in response to tissue injury and microbial infection. GRO-beta and GRO-gamma are closely related to GRO-alpha and share 90% and 86% amino acid sequence homology, respectively, with GRO-alpha. Receptor-binding studies have demonstrated that GRO-alpha, -beta, and -gamma signal mainly through G protein-coupled receptors CXCR1 and CXCR2 (Ahuja & Murphy). GRO-beta is expressed in epithelial cells, monocytes, fibroblasts, and melanocytes and is further induced during inflammatory, epithelialization, and angiogenic processes, for example during the wound healing process of human burn wounds (Zaja-Milatovic & Richmond). GRO-beta also stimulates mitogenesis in certain human melanoma cells (Unemori et al.).
Subtype
Cytokines
Alternative Names
CXCL2, GRO2, Growth regulated protein, Macrophage inflammatory protein-2α, Melanoma growth stimulatory activity, MGSAβ, MIP-2α
Cell Type
Cancer Cells and Cell Lines, Endothelial Cells, Granulocytes and Subsets
Species
Human
Area of Interest
Angiogenic Cell Research, Cancer, Epithelial Cell Biology, Immunology
Molecular Weight
7.9 kDa
Purity
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant GRO-beta (CXCL2) was tested by its ability to mobilize Ca2+ in CHO-K1/Gα15/hCXCR2 cells (human Gα15 and human CXCR2 stably expressed in CHO-K1 cells). Ca2+ mobilization was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which Ca2+ mobilization is at 50% of maximum. The EC50 in the above example is less than 0.2 μg/mL. (B) 2 μg of Human Recombinant GRO-beta (CXCL2) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant GRO-beta (CXCL2) Catalog #
78112.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant GRO-beta (CXCL2) Catalog #
78112.1 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Mammary Epithelial Cell Research
Workflow Stages for Monocyte Research
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