产品号 #100-0558_C
蒽环霉素抗生素;抑制DNA拓扑异构酶II
阿霉素是一种蒽环类抗生素,可插入DNA并抑制DNA拓扑异构酶II (Burridge等人;Lorenzo等人)。阿霉素表现出心脏毒性作用,包括产生活性氧、抑制DNA拓扑异构酶II和释放肌浆网中的钙(Burridge等)。本品以分子的盐酸盐形式供应。
癌症研究
·诱导人内皮细胞凋亡(Lorenzo等人)。
Alternative Names
DOX
Cell Type
Cancer Cells and Cell Lines, Endothelial Cells
Area of Interest
Cancer, Endothelial Cell Biology
CAS Number
25316-40-9
Chemical Formula
C27H29NO11 • HCl
Molecular Weight
580 g/mol
Purity
≥ 98%
Pathway
p53
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Molecular Weight | 580 g/mol |
---|---|
Alternative Names | DOX |
Cas Number | 25316-40-9 |
Chemical Formula | C27H29NO11 • HCl |
Purity | ≥ 98% |
Pathway | p53 |