产品号 #100-1161_C
磷酸二酯酶抑制剂
概述
用双嘧达莫（一种双向核苷转运抑制剂）抑制磷酸二酯酶（PDE）家族酶（PDE8 IC50 = 9 μM） （Fisher et al., 1998）。PDE是一种分解环磷酸腺苷（cAMP）和环鸟苷（cGMP）的酶，它们是参与多种不同信号转导途径的次级信使（Harker & Kadatz）。双嘧达莫还能抑制血小板、红细胞和内皮细胞对腺苷的摄取，从而导致细胞外腺苷浓度和细胞内cAMP的增加（Brown等）。
双嘧达莫用于：
癌症研究
·通过抑制甾醇调节元件结合蛋白2 （SREBP2）的裂解，阻止他汀类药物诱导的3-羟基-3-甲基戊二酰辅酶A还原酶（HMGCR）的上调，诱导急性髓性白血病（AML）细胞凋亡（Pandyra & Penn）。
·通过降低活化的β-catenin、phospho-ERK1/2和phospho-p65，并使IkBα的表达增加一倍，从而降低乳腺癌细胞（4T1-Luc和MDA-MB-231T细胞）的肿瘤生长和转移（Spano等）。
·通过自噬损伤降低癌细胞活力（Chang等）；Mello等人；托马斯等人)。
Cell Type
Cancer Cells and Cell Lines
Area of Interest
Cancer
CAS Number
58-32-2
Chemical Formula
C24H40N8O4
Molecular Weight
504.6 g/mol
Purity
≥ 98%
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
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更多信息
| Molecular Weight | 504.6 g/mol |
|---|---|
| Cas Number | 58-32-2 |
| Chemical Formula | C24H40N8O4 |
| Purity | ≥ 98% |
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