产品号 #100-1166_C
HIV-1蛋白酶抑制剂
总览
阿扎那韦抑制HIV-1蛋白酶（IC50 = 2 ~ 5 nM；Wood）。阿扎那韦是一种含氮肽类，与HIV-1蛋白酶结合并阻止其产生病毒蛋白，使病毒无传染性，因为当HIV-1蛋白酶被抑制时，不会产生成熟的病毒颗粒（Kohl et al.）。阿扎那韦也是细胞色素P450同工酶3A （CYP3A）的底物和抑制剂，p -糖蛋白的诱导剂（Perloff et al.）。
阿扎那韦用于：
癌症研究
·通过激活半胱天冬酶-4诱导恶性胶质瘤细胞内质网应激反应，导致细胞死亡（Pyrko et al.）
·在增殖的人骨髓间充质干细胞中诱导衰老和氧化应激（Hernandez-Vallejo et al.）
细胞类型
癌细胞及细胞系
研究领域
癌症
CAS 编号
198904-31-3
化学式
C38H52N6O7
分子量
704.9 克/摩尔
纯度
≥98%
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
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Educational Materials (3)
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更多信息
| Molecular Weight | 704.9 g/mol |
|---|---|
| Cas Number | 198904-31-3 |
| Chemical Formula | C38H52N6O7 |
| Purity | ≥ 98% |
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