产品号 #100-1166_C
HIV-1蛋白酶抑制剂
概述
阿扎那韦抑制HIV-1蛋白酶（IC50 = 2 ~ 5 nM）；木头)。阿扎那韦是一种阿扎肽，与HIV-1蛋白酶结合并阻止其产生病毒蛋白，使病毒无传染性，因为当HIV-1蛋白酶被抑制时，不会产生成熟的病毒粒子（Kohl等人）。阿扎那韦也是细胞色素P450同工酶3A （CYP3A）的底物和抑制剂，p -糖蛋白的诱诱剂（Perloff等）。
Atazanavir被用于：
癌症研究
·通过激活caspase-4诱导恶性胶质瘤细胞内质网应激反应，导致细胞死亡（Pyrko等）。
·在增殖的人骨髓间充质干细胞中诱导衰老和氧化应激（Hernandez-Vallejo等人）。
Cell Type
Cancer Cells and Cell Lines
Area of Interest
Cancer
CAS Number
198904-31-3
Chemical Formula
C38H52N6O7
Molecular Weight
704.9 g/mol
Purity
≥ 98%
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Atazanavir Catalog #
100-1166 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Atazanavir Catalog #
100-1166 Lot #
All Language
English Resources and Publications
Educational Materials (3)
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更多信息
| Molecular Weight | 704.9 g/mol |
|---|---|
| Cas Number | 198904-31-3 |
| Chemical Formula | C38H52N6O7 |
| Purity | ≥ 98% |
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