产品号 #100-1166_C
HIV-1蛋白酶抑制剂
阿扎那韦抑制HIV-1蛋白酶(IC50 = 2 ~ 5 nM);木头)。阿扎那韦是一种阿扎肽,与HIV-1蛋白酶结合并阻止其产生病毒蛋白,使病毒无传染性,因为当HIV-1蛋白酶被抑制时,不会产生成熟的病毒粒子(Kohl等人)。阿扎那韦也是细胞色素P450同工酶3A (CYP3A)的底物和抑制剂,p -糖蛋白的诱诱剂(Perloff等)。
Atazanavir被用于:
癌症研究
·通过激活caspase-4诱导恶性胶质瘤细胞内质网应激反应,导致细胞死亡(Pyrko等)。
·在增殖的人骨髓间充质干细胞中诱导衰老和氧化应激(Hernandez-Vallejo等人)。
Cell Type
Cancer Cells and Cell Lines
Area of Interest
Cancer
CAS Number
198904-31-3
Chemical Formula
C38H52N6O7
Molecular Weight
704.9 g/mol
Purity
≥ 98%
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
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Molecular Weight | 704.9 g/mol |
---|---|
Cas Number | 198904-31-3 |
Chemical Formula | C38H52N6O7 |
Purity | ≥ 98% |
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