抗Ym1抗体,多克隆

兔多克隆IgG抗体,抗小鼠Ym1

产品号 #(选择产品)

产品号 #60130_C

兔多克隆IgG抗体,抗小鼠Ym1

总览

Ym1是一种~45 kDa的分泌蛋白,由激活的小鼠腹腔巨噬细胞在寄生虫感染引起的炎症反应中合成。Ym1是中性粒细胞中的颗粒蛋白,已从mev/mev和SHIP(含SH2的肌醇5′磷酸酶)敲除小鼠支气管肺泡灌洗液中形成的嗜酸性晶体中被纯化出来。在小鼠中形成的嗜酸性晶体被认为在组织学上与在人体中发现的Charcot-Leyden晶体相同。Ym1与T淋巴细胞来源的嗜酸性粒细胞趋化因子(ECF-L)同源,但在嗜酸性粒细胞中仅引起弱趋化反应。Ym1与肝素、GlcN低聚物和硫酸乙酰肝素结合。Ym1属于几丁质酶相关的蛋白质家族,但不具有几丁质酶活性。

亚型
一抗
 
靶抗原
Ym1
 
别名
β-N-乙酰己糖胺酶Ym1,Chi3l3,几丁质酶样蛋白3,ECF-L,嗜酸性粒细胞趋化因子,嗜酸性粒细胞趋化因子-L,分泌蛋白Ym1
 
活性物种
小鼠
 
偶联
未偶联的
 
宿主物种

 
细胞类型
其它细胞系
 
种属
小鼠,其它细胞系
 
应用
流式细胞术,免疫印迹,免疫荧光,免疫组化
 
研究领域
免疫
 
克隆
Not applicable
 
基因编号
12655
 
同种型
IgG
 

Data Figures

(A) Flow cyometry analysis of peritoneal macrophages from normal (+/+) and SHIP knockout (-/-) mice. Cells were fixed, permeabilized, and labeled with an isotype control antibody (red) or Anti-Ym1 Antibody, Polyclonal, followed by an Alexa Fluor® 488-conjugated anti-rabbit antibody (blue).

(B) Monocytes isolated from bone marrow of normal and SHIP knockout mice were labeled with Anti-Ym1 Antibody, Polyclonal, followed by an Alexa Fluor® 488-conjugated anti-rabbit antibody.

(C) Western blot analysis of cell lysates from mouse peritoneal macrophages isolated from normal and SHIP knockout mice and probed with Anti-Ym1 Antibody, Polyclonal. Ym1 has a predicted molecular mass of ~45 kDa

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
60130
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
60130
Lot #
All
Language
English

Resources and Publications

Educational Materials (2)

更多信息

更多信息
Species Mouse, Other
Clone Not applicable
Gene Id 12655
Alternative Names beta-N-acetylhexosaminidase Ym1, Chi3l3, chitinase-like protein 3, ECF-L, eosinophil chemotactic cytokine, eosinophil chemotactic factor-L, secreted protein Ym1
Isotype IgG
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