产品号 #100-1345_C
Rabbit monoclonal antibody against human Synaptophysin
概述
This rabbit monoclonal antibody (clone 249) reacts with synaptophysin, a 38 kDa integral transmembrane protein possessing four transmembrane domains and a major small synaptic synaptic vesicle protein. Use this recombinant monoclonal antibody in applications requiring detection of synaptophysin, such as immunohistochemistry (IHC), immunocytochemistry (ICC), and immunofluorescence (IF). This antibody clone has been verified for labeling synaptophysin-positive puncta in hPSC-derived forebrain-type neurons generated with STEMdiff™ Forebrain Neuron Differentiation Kit (Catalog #08600) and STEMdiff™ Forebrain Neuron Maturation Kit (Catalog #08605).
It interacts with a variety of different motor proteins and synaptic vesicles including dynamin I, myosin V, vesicular proton pump V-ATPase, and adaptor protein 1 (AP-1). Synaptophysin is extensively involved in vesicular functions such as protein sorting and priming, as well as synapse formation, exocytosis, and endocytosis. Synaptophysin is also a potent marker of axonal damage; synaptophysin was discovered colocalized with amyloid precursor protein (APP), a marker of axonal damage in patients with multiple sclerosis. Synaptophysin deletion in knock-out mice have been correlated with reduced spatial learning and impaired object novelty recognition.
Subtype
Primary Antibodies
Target Antigen
SYP
Alternative Names
MRX96, MRXSYP, XLID96
Reactive Species
Human
Conjugation
Unconjugated
Host Species
Rabbit
Cell Type
Neural Cells, PSC-Derived, Neurons
Species
Human
Application
Immunocytochemistry
Area of Interest
Neuroscience, Stem Cell Biology
Clone
249
Gene ID
6855
Isotype
IgG
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
