产品号 #100-1064_C
Rabbit polyclonal antibody against human, mouse, rat cytokeratin 20
概述
This rabbit polyclonal antibody reacts with human, mouse, and rat cytokeratin 20, a low molecular weight, type I cytokeratin that is a major component of mature enterocytes and goblet cells. Cytokeratin 20 is expressed primarily in the gastrointestinal (GI) epithelium, urothelium, and Merkel cells and serves as a marker of GI differentiation. Use this polyclonal antibody in applications requiring detection of cytokeratin 20, such as western blotting (WB) assays, immunohistochemistry protocols (IHC-P), or immunofluorescence (IF). It is verified for use with immunocytochemistry (ICC).
The cytokeratin 20 protein is responsible for the structural integrity of epithelial cells and maintains the intermediate filament organization in the intestinal epithelia. Cytokeratin 20 is also a useful marker of pancreatic and colorectal cancer and has been detected in adenocarcinomas of the colon, pancreas, stomach and biliary tract. Expression of cytokeratin 20 has also been associated with the progression and metastasis of breast cancer, suggesting that it may be a biomarker in predicting breast cancer prognosis.
Subtype
Primary Antibodies
Target Antigen
Cytokeratin 20
Alternative Names
CK20, K20, KRT20, keratin 20
Reactive Species
Human
Conjugation
Unconjugated
Host Species
Rabbit
Cell Type
Intestinal Cells
Species
Human, Mouse, Rat
Application
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting
Area of Interest
Organoids
Clone
Not applicable
Gene ID
54474
Isotype
Not applicable
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (4)
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
