产品号 #100-1067_C
兔多克隆抗体,抗人、小鼠、大鼠嗜铬粒蛋白A
该兔多克隆抗体与人、小鼠和大鼠嗜铬粒蛋白A反应,嗜铬粒蛋白A是一种存在于神经元和内分泌细胞胞质囊泡中的分泌蛋白。该多克隆抗体适用于需要检测嗜铬粒蛋白A的实验应用,如蛋白印迹(WB)和免疫组化(IHC-P),并已验证可用于免疫细胞化学(ICC)实验。嗜铬粒蛋白A的蛋白水解片段可形成功能性肽段,通过自分泌和旁分泌过程帮助维持体内平衡。嗜铬粒蛋白A及其衍生物分别在胰腺和脂肪细胞内抑制胰岛素和瘦素的分泌中发挥关键作用。除了内分泌功能外,嗜铬粒蛋白A还能通过抑制动脉血管收缩来调节心血管功能。铬粒蛋白A的其他翻译后衍生物还参与炎症反应,并对细菌和真菌具有较强的抗菌活性。血浆嗜铬粒蛋白A的升高也是诊断神经内分泌肿瘤的重要生物标志物。
亚型
一抗
靶抗原
Chromogranin A
别名
CGA,CHGA,Chromogranin A,甲状旁腺分泌蛋白1,SP-I
活性物种
人
偶联
未偶联的
宿主物种
兔
细胞类型
肠道细胞
种属
人,小鼠,大鼠
应用
免疫细胞化学,免疫荧光,免疫组化,Western印迹
研究领域
类器官
克隆
Not applicable
基因编号
1113
同种型
Not applicable
Figure 1. Anti-Human Chromogranin A Antibody, Polyclonal is Suitable for Staining Primary Differentiated Intestinal Organoid Sections
Primary differentiated intestinal organoid sections from L1 ALI ileal line were deparaffinized and rehydrated with water. The sections went through an antigen retrieval step, were blocked, and then labeled with Anti-Human Chromogranin A Antibody, Polyclonal, followed by Goat Anti-Rabbit IgG (H+L) Antibody, Polyclonal, iFluor™ 488 (Catalog #100-1082). Nuclei were counter-stained with DAPI (blue). Inset shows cells labeled with a rabbit IgG isotype control antibody, followed by Goat Anti-Rabbit IgG (H+L) Antibody, Polyclonal, iFluor™ 488 (with DAPI staining).
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
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Species | Human, Mouse, Rat |
---|---|
Clone | Not applicable |
Gene Id | 1113 |
Alternative Names | CGA, CHGA, Chromogranin A, Parathyroid Secretory Protein 1, SP-I |
Isotype | Not applicable |
DNA标记染料
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