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抗人 CD81 (TAPA-1) 抗体，克隆 5A6

小鼠单克隆抗体，抗人、恒河猴、食蟹猴CD81，未偶联
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产品号 #100-0209_C

小鼠单克隆抗体，抗人、恒河猴、食蟹猴CD81，未偶联

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总览

5A6 抗体与位于人 CD81（TAPA-1）的大细胞外环（EC2）的表位发生反应。CD81 的表达范围很广，包括 B 细胞、T 细胞、NK 细胞、单核细胞、树突状细胞、胸腺细胞、内皮细胞和成纤维细胞的表面。它也是细胞外囊泡的特征标志物。

CD81 是一种 26 kDa 的非糖基化 III 型跨膜蛋白，属于四跨蛋白（Tetraspanin）家族。Tetraspanin包含四个跨膜结构域、两个胞外环以及短的胞质 N 端和 C 端。CD81 与许多整合素、共受体和其他蛋白结合，在质膜上形成多分子复合物，称为四跨蛋白富集微域。近膜半胱氨酸残基的棕榈酰化对其与其他蛋白和质膜的结合非常重要。

CD81 可调节多种生物功能，包括细胞粘附和融合、细胞迁移和增殖。例如，CD81 与 CD19 和 CD21 一起构成 B 细胞上 B 细胞受体的共受体。当 CD81 与 CD19 复合时，5A6 抗体的表位被隐藏起来，但当 B 细胞被激活后，5A6 抗体的表位就可以被暴露。CD81突变与普通变异性免疫缺陷症（CVID）有关。CD81 还与介导丙型肝炎病毒进入细胞有关。

亚型
一抗
 
靶抗原
CD81
 
别名
CVID6
 
活性物种
African Green Monkey，Baboon，Chimpanzee，Cynomolgus，人，Rhesus
 
偶联
未偶联的
 
宿主物种
小鼠
 
细胞类型
其它细胞系
 
应用
流式细胞术，Western印迹
 
研究领域
细胞外囊泡研究
 
克隆
5A6
 
基因编号
975
 
同种型
IgG1，kappa
 

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Data Figures

Data showing western blot analysis of extracellular vesicles isolated from mesenchymal stromal cell-conditioned medium with Anti-Human CD81 (TAPA-1) Antibody, Clone 5A6 and flow cytometry analysis of human peripheral blood mononuclear cells labeled with Anti-Human CD81 (TAPA-1) Antibody, Clone 5A6.

Figure 1. Analysis of Anti-Human CD81 (TAPA-1) Antibody, Clone 5A6 with Western Blot and Flow Cytometry

Extracellular vesicles (EVs) isolated from mesenchymal stromal cell (MSC)-conditioned medium using a 2 mL EV size exclusion chromatography column were analysed with (A) western blot analysis with Anti-Human CD81 (TAPA-1) Antibody, Clone 5A6. Lanes (left to right) were loaded with isolated fractions 9, 10, and 11, respectively. Further validation was performed by flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; viable lymphocytes were gated for analysis) stimulated with phorbol myristate acetate (PMA) and ionomycin and then (B) labeled with Anti-Human CD81 (TAPA-1) Antibody, Clone 5A6, followed by a goat anti-mouse IgG1 antibody, APC (filled histogram), or Anti-Dextran Antibody, Clone DX1 (Catalog #60026) as an isotype control, followed by a goat anti-mouse IgG1 antibody, APC (solid line histogram), or (C) labeled with Anti-Dextran Antibody, Clone DX1 (Catalog #60026) as an isotype control, followed by a goat anti-mouse IgG1 antibody, APC, or (D) labeled with Anti-Human CD81 (TAPA-1) Antibody, Clone 5A6, followed by a goat anti-mouse IgG1 antibody, APC.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD81 (TAPA-1) Antibody, Clone 5A6
Catalog #
100-0209
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD81 (TAPA-1) Antibody, Clone 5A6
Catalog #
100-0209
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Clone 5A6
Gene Id 975
Alternative Names CVID6
Isotype IgG1, kappa
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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