产品号 #100-0139_C
Mouse monoclonal antibody against human, rhesus, cynomolgus CD63, unconjugated
概述
The H5C6 antibody reacts with an extracellular epitope on human CD63, a 30-60 kDa type III lysosomal glycoprotein and member of the tetraspanin family. CD63 exhibits broad expression, including on the surface of monocytes, macrophages, activated basophils, fibroblasts, smooth muscle cells, and activated platelets. CD63 is found in late endosomes, lysosomes, and secretory vesicles, and cycles among these compartments. It is also a marker characteristic of extracellular vesicles.
Tetraspanins like CD63 contain four transmembrane domains, two extracellular loops, and short cytoplasmic N- and C-termini. CD63 associates with several integrins, co-receptors, and other proteins to form multimolecular complexes in the plasma membrane called tetraspanin-enriched microdomains. The protein is involved in several cellular processes, including cell activation, adhesion, differentiation, and tumor invasion. CD63 has been implicated in tumor progression, and a deficiency of the protein is associated with Hermansky-Pudlak syndrome, a rare autosomal recessive disorder presenting with platelet dysfunction and defects in lysosomal storage.
Subtype
Primary Antibodies
Target Antigen
CD63
Alternative Names
gp55
Reactive Species
African Green Monkey, Baboon, Capuchin Monkey, Chimpanzee, Cynomolgus, Human, Rhesus
Conjugation
Unconjugated
Host Species
Mouse
Cell Type
Other
Application
Flow Cytometry, Western Blotting
Area of Interest
Extracellular Vesicle Research
Clone
H5C6
Gene ID
967
Isotype
IgG1, kappa
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
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Resources and Publications
Educational Materials (4)
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
