产品号 #100-1651_C
聚(adp核糖)聚合酶1 (PARP1)抑制剂
AG-14361是一种选择性、竞争性的聚(adp -核糖)聚合酶1 (PARP1)抑制剂,可增强化疗药物在癌细胞中的有效性;Ki = 6.3 nM)。PARP1是一种关键参与DNA修复途径的核酶。当被DNA损伤激活时,PARP1以烟酰胺腺嘌呤二核苷酸(NAD+)为底物催化聚合(adp -核糖)的产生(Ray Chaudhari & Nussenzweig)。生物化学学报,2017)。AG-14361与NAD+竞争结合到PARP1的催化位点,抑制酶的活性(Calabrese等)。国家癌症研究所,2004)。
AG-14361被用于:
癌症研究
·增强化疗药物和放射治疗在许多人类癌细胞系中的活性(Calabrese等)。中华癌症杂志,2004;De Soto等人。临床肿瘤学杂志,2010;史密斯等人。临床癌症研究,2005)。
·在结肠癌小鼠异种移植模型中,联合替莫唑胺刺激肿瘤完全消退(Calabrese等)。国家癌症研究所,2004)。
Alternative Names
Not applicable
Cell Type
Cancer Cells and Cell Lines
Area of Interest
Cancer
CAS Number
328543-09-5
Chemical Formula
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Molecular Weight | 320.4 g/mol |
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Alternative Names | Not applicable |
Cas Number | 328543-09-5 |
Chemical Formula | C19H20N4O |
Purity | ≥ 98% |
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