ag - 14361

聚(adp核糖)聚合酶1 (PARP1)抑制剂

产品号 #(选择产品)

产品号 #100-1651_C

聚(adp核糖)聚合酶1 (PARP1)抑制剂

概述

AG-14361是一种选择性、竞争性的聚(adp -核糖)聚合酶1 (PARP1)抑制剂,可增强化疗药物在癌细胞中的有效性;Ki = 6.3 nM)。PARP1是一种关键参与DNA修复途径的核酶。当被DNA损伤激活时,PARP1以烟酰胺腺嘌呤二核苷酸(NAD+)为底物催化聚合(adp -核糖)的产生(Ray Chaudhari & Nussenzweig)。生物化学学报,2017)。AG-14361与NAD+竞争结合到PARP1的催化位点,抑制酶的活性(Calabrese等)。国家癌症研究所,2004)。

AG-14361被用于:

癌症研究
·增强化疗药物和放射治疗在许多人类癌细胞系中的活性(Calabrese等)。中华癌症杂志,2004;De Soto等人。临床肿瘤学杂志,2010;史密斯等人。临床癌症研究,2005)。
·在结肠癌小鼠异种移植模型中,联合替莫唑胺刺激肿瘤完全消退(Calabrese等)。国家癌症研究所,2004)。

Alternative Names
Not applicable
 
Cell Type
Cancer Cells and Cell Lines
 
Area of Interest
Cancer
 
CAS Number
328543-09-5
 
Chemical Formula

C19H20N4O
 
Molecular Weight
320.4 g/mol
 
Purity
≥ 98%
 

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
AG-14361
Catalog #
100-1651
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
AG-14361
Catalog #
100-1651
Lot #
All
Language
English

更多信息

更多信息
Molecular Weight 320.4 g/mol
Alternative Names Not applicable
Cas Number 328543-09-5
Chemical Formula C19H20N4O
Purity ≥ 98%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
版权 © 2025 STEMCELL Technologies 技术有限公司。保留所有权利。