产品号 #72082_C
Notch pathway inhibitor; Inhibits γ-secretase
概述
DAPT is an inhibitor of the γ-secretase complex. Notch is a key target of γ-secretase, therefore DAPT indirectly inhibits the Notch pathway. Other targets of γ-secretase that would be influenced by DAPT include amyloid precursor protein, E-cadherin, and ErbB4. (Dovey et al.).
MAINTENANCE AND SELF-RENEWAL
· Reduces colony-forming efficiency of mouse neural stem cells (Androutsellis-Theotokis et al.).
· Enhances radiation-induced cell death of glioma stem cells (Wang et al.).
DIFFERENTIATION
· Promotes differentiation of nociceptors from human pluripotent stem cells, in combination with several other small molecules (Chambers et al.).
· Promotes differentiation of neurons from human and mouse embryonic stem (ES) cells (Crawford and Roelink, Elkabetz et al.).
· Promotes differentiation of retinal pigment epithelium from mouse ES cells (Osakada et al.).
· Promotes differentiation of pancreatic cells from human pluripotent stem cells (D'Amour et al.).
CANCER RESEARCH
· Reduces mammosphere-forming efficiency of breast cancer cell lines and ductal carcinoma in situ cells (Farnie et al., Harrison et al.).
Alternative Names
GSI-IX;LY-374973
Cell Type
Cancer Cells and Cell Lines, Endoderm, PSC-Derived, Mammary Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons, Pancreatic Cells, Pluripotent Stem Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Differentiation
Area of Interest
Cancer
CAS Number
208255-80-5
Chemical Formula
C₂₃H₂₆F₂N₂O₄
Molecular Weight
432.5 g/mol
Purity
≥ 95%
Pathway
Notch
Target
γ-Secretase
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
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Resources and Publications
Educational Materials (5)
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
