产品号 #74012_C
Activin/NODAL/TGF-β pathway inhibitor; Inhibits CK1, ALK5 and p38 MAPK
概述
D4476 is a selective, potent, and cell-permeant inhibitor of casein kinase (CK) 1 (Rena et al.). It inhibits CK1 and CK1δ from S. pombe (IC50 = 200 nM and 300 nM, respectively; Bain et al.; Rena et al.). It also inhibits transforming growth factor β1 (TGF-β1) type I receptor (ALK5) with IC50 = 500 nM (Rena et al.).
REPROGRAMMING
· Along with forskolin (Catalog #72112) and 2-methyl-5-hydroxytryptamine, reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.).
· Reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.).
CANCER RESEARCH
· Induces apoptosis of multiple myeloma cell lines (Hu et al.).
· Exhibits anti-leukemic activity by selectively killing leukemia stem cells over normal hematopoietic stem and progenitor cells (Järås et al.).
Cell Type
Hematopoietic Stem and Progenitor Cells, Pluripotent Stem Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Reprogramming
Area of Interest
Cancer, Stem Cell Biology
CAS Number
301836-43-1
Chemical Formula
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₄O
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Purity
≥ 98%
Pathway
Activin/Nodal/TGFβ, p38 MAPK
Target
ALK5
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
D4476 Catalog #
74012 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Hematopoietic Stem and Progenitor Cell Research
Workflow Stages for Mouse Pluripotent Stem Cell Research
Resources and Publications
Educational Materials (3)
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