产品号 #73952_C
Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein
概述
Compound E is a potent, cell-permeable, selective inhibitor that blocks the cleavage of both gamma-secretase and the Notch intracellular domain with similar IC50 values, ranging from 0.24 to 0.37 nM (Beher et al.; Seiffert et al.).
DIFFERENTIATION
· Inhibits growth, differentiation, and motility of neuroblastoma cells (Ferrari-Toninelli et al.).
· Accelerates the differentiation of human embryonic stem cells into primitive neural stem cells (Li et al.).
Cell Type
Brain Tumor Stem Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Differentiation, Maintenance
Area of Interest
Neuroscience
CAS Number
209986-17-4
Chemical Formula
<div>
C<font face="Cambria" math>₂₇</font>H<font face="Cambria Math">₂₄</font>F<fontface="cambria math>
₂N
<font face="Cambria Math">₄</font>O
<fontface="cambria math>
₃
</fontface="cambria>
</fontface="cambria>
</div>"
Purity
≥ 98%
Pathway
Notch
Target
γ-Secretase
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Compound E Catalog #
73952, 73954 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Compound E Catalog #
73952, 73954 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Brain Tumor Stem Cell Research
Workflow Stages for hPSC-Derived Neural Cell Research
Resources and Publications
Educational Materials (3)
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