产品号 #100-1625_C
Rat monoclonal antibody against mouse CD86 (B7-2)
概述
This monoclonal (clone GL-1) antibody reacts with mouse cluster of differentiation 86 (CD86; also known as B7-2), an ~80 kDa immunoglobulin superfamily member and a type I transmembrane glycoprotein. Both CD80 and CD86 are ligands of the T cell surface proteins CD28 and CD152 (CTLA-4); however, CD86 is expressed earlier in the immune response compared to CD80. CD86 is also involved in immunoglobulin class-switching and triggering of natural killer cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 with a 20- to 100-fold higher affinity than CD28 and deliver an inhibitory signal to T cells as well as down regulate the immune response. CD86 has been used as a phenotypic marker for differentiating cells. This antibody can be used as a marker to assess classically activated M1 murine macrophages. Use this recombinant monoclonal antibody in applications requiring detection of CD86, such as flow cytometry (FC).
Subtype
Primary Antibodies
Target Antigen
CD86 (B7-2)
Alternative Names
B70, B7-2, B7-2 antigen, B-lymphocyte activation antigen B7-2, Ly-58
Reactive Species
Mouse
Conjugation
APC, FITC, PE
Host Species
Rat
Cell Type
B Cells, Dendritic Cells, Macrophages
Species
Mouse
Application
Flow Cytometry
Area of Interest
Immunology
Clone
GL-1
Gene ID
12524
Isotype
IgG2a, kappa
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Mouse CD86 (B7-2) Antibody, Clone GL-1, APC Catalog #
100-1627 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD86 (B7-2) Antibody, Clone GL-1, FITC Catalog #
100-1626 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD86 (B7-2) Antibody, Clone GL-1, PE Catalog #
100-1625 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD86 (B7-2) Antibody, Clone GL-1, APC Catalog #
100-1627 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD86 (B7-2) Antibody, Clone GL-1, FITC Catalog #
100-1626 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD86 (B7-2) Antibody, Clone GL-1, PE Catalog #
100-1625 Lot #
All Language
English Resources and Publications
Educational Materials (3)
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