产品号 #100-1628_C
Rat monoclonal antibody against mouse CD127
概述
This monoclonal antibody (clone A7R34) reacts with mouse cluster of differentiation 127 (CD127), a 60 - 90 kD type I transmembrane glycoprotein involved in the regulation of lymphopoiesis. CD127 is expressed on thymocytes, B cell precursors, T cells, and myeloid cells at the cell surface as a heterodimer with the common gamma chain (also known as CD132). This complex acts as a receptor for interleukin-7 (IL-7), which is an important cytokine in T and B cell development as well as in mature T cell homeostasis. Use this recombinant monoclonal antibody in applications requiring detection of CD127, such as flow cytometry (FC).
Thymic stromal lymphopoietin (TSLP), a second cytokine, also binds to the receptor complex of CD127 and is involved in trigger activation of dendritic cells, allergy, and autoimmunity. CD127 has been reported to be a useful marker for identifying memory and effector T cells. The A7R34 antibody clone has been shown to block IL-7Rα signaling when administered in vivo.
Subtype
Primary Antibodies
Target Antigen
CD127
Alternative Names
IL-7Ra, Interleukin-7 receptor alpha
Reactive Species
Mouse
Conjugation
APC, PE, PE-Cyanine7
Host Species
Rat
Cell Type
B Cells, Myeloid Cells, T Cells
Species
Mouse
Application
Flow Cytometry
Area of Interest
Immunology
Clone
A7R34
Gene ID
16172
Isotype
IgG2a, kappa
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Mouse CD127 Antibody, Clone A7R34, APC Catalog #
100-1629 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD127 Antibody, Clone A7R34, PE Catalog #
100-1628 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD127 Antibody, Clone A7R34, PE-Cy7 Catalog #
100-1630 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD127 Antibody, Clone A7R34, APC Catalog #
100-1629 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD127 Antibody, Clone A7R34, PE Catalog #
100-1628 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD127 Antibody, Clone A7R34, PE-Cy7 Catalog #
100-1630 Lot #
All Language
English Resources and Publications
Educational Materials (3)
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