产品号 #60124_C
Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD14
概述
The MoP9 antibody reacts with CD14, a 53 - 55 kDa glycosylphosphatidylinositol (GPI)-anchored transmembrane glycoprotein expressed at high levels on the surface of peripheral blood monocytes and macrophages, and at lower levels on granulocytes. An approximate 10-fold difference in expression levels between monocytes/macrophages and granulocytes makes CD14 a useful marker for distinguishing these cell populations. CD14 is also found on tissue macrophages, Langerhans cells, and dendritic cells. CD14 functions as a high-affinity receptor for complexes of lipopolysaccharide (LPS) and serum LPS-binding protein and modulates LPS-dependent signal transduction during the immune response to gram-negative pathogens by acting as a co-receptor for TLR 4 and MD-2. This triggers activation of NF-κB, cytokine secretion, and induction of the inflammatory response. Two soluble forms of CD14 have also been described (~48 and ~55 kDa).
Subtype
Primary Antibodies
Target Antigen
CD14
Reactive Species
Human
Conjugation
FITC
Host Species
Mouse
Cell Type
Monocytes
Species
Human
Application
Cell Isolation, Flow Cytometry
Area of Interest
Immunology
Clone
MoP9
Gene ID
929
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Human CD14 Antibody, Clone MoP9, FITC Catalog #
60124FI Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD14 Antibody, Clone MoP9, FITC Catalog #
60124FI Lot #
All Language
English Resources and Publications
Educational Materials (2)
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